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Behavioral Nudge for Genetic Predisposition
N/A
Recruiting
Led By Katherine L Nathanson, MD
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
18 years of age or older
diagnosed with one of the study conditions
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 years
Awards & highlights
No Placebo-Only Group
Summary
This trial aims to find new ways to deliver genetic testing results that can change medical management beyond traditional genetic counseling visits. The study will use non-geneticist clinicians and patient nudges in a randomized clinical
Who is the study for?
Adults diagnosed with specific conditions like Alzheimer's, various heart diseases, and genetic predispositions that can change medical management based on genetic testing results. Participants must be over 18 years old.
What is being tested?
The trial is testing a new approach to genomic medicine using electronic health records (EHR) to nudge clinicians and patients towards the use of genetic testing. It involves direct test ordering, EHR algorithms for patient identification, and behavioral economics methods.
What are the potential side effects?
Since this trial focuses on behavioral nudges rather than medications or invasive procedures, traditional physical side effects are not expected. However, there may be psychological impacts or changes in healthcare decisions due to the nudging.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Select...
I have been diagnosed with a condition being studied.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 years
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Rate of Genetic Testing
Secondary study objectives
Rate of Clinician actions
Rate of Genetic Test Orders/Referrals
Rate of Pathogenic variants and VUS
+1 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
6Treatment groups
Active Control
Group I: Clinician BPA refer plus patient nudgeActive Control1 Intervention
Clinician will receive a nudge to refer patient for genetic testing and the patient will receive a text message encouraging them to speak with their clinician about genetic testing.
Group II: Clinician nudge, referActive Control1 Intervention
Clinician will receive a nudge to refer the patient for genetic testing.
Group III: Generic BPA; no nudgeActive Control1 Intervention
Usual care
Group IV: Clinician nudge, orderActive Control1 Intervention
Clinician will receive a nudge to order genetic testing for the patient.
Group V: Patient nudgeActive Control1 Intervention
The patient will receive a text message encouraging them to speak with their clinician about genetic testing.
Group VI: Clinician BPA order plus patient nudgeActive Control1 Intervention
Clinician will receive a nudge to order genetic testing for the patient and the patient will receive a text message encouraging them to speak with their clinician about genetic testing.
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Who is running the clinical trial?
University of PennsylvaniaLead Sponsor
2,071 Previous Clinical Trials
42,712,922 Total Patients Enrolled
Katherine L Nathanson, MDPrincipal InvestigatorUniversity of Pennsylva
1 Previous Clinical Trials
1,238 Total Patients Enrolled
Robert Schnoll, PhDPrincipal InvestigatorUniversity of Pennsylva
3 Previous Clinical Trials
1,252 Total Patients Enrolled
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