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Semantic Feature Analysis Treatment for Aphasia

N/A
Recruiting
Led By William D Hula, Ph.D.
Research Sponsored by VA Pittsburgh Healthcare System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No participation in any other speech-language treatment during this study, including follow-up period
6 months post-onset of aphasia due to unilateral left-hemisphere (LH) stroke
Must not have
Right Hemisphere stroke
Neurological disease other than stroke
Timeline
Screening 3 weeks
Treatment Varies
Follow Up (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
Awards & highlights
No Placebo-Only Group

Summary

This trial is studying two different versions of an existing treatment for naming impairments in aphasia, to see which one is more effective. It will also look at the brain and cognitive processes behind why one treatment works better than the other.

Who is the study for?
This trial is for individuals who have aphasia due to a stroke in the left side of their brain, at least 6 months ago. They must be able to manage daily activities on their own or with help from a caregiver, and not have uncontrolled health issues like seizures. Participants should speak English as their first language and not be involved in other speech treatments during the study.
What is being tested?
The study tests two versions of Semantic Feature Analysis treatment for naming impairments caused by aphasia. It's a randomized controlled trial where participants are assigned randomly to one of the two treatment groups to see which is more effective.
What are the potential side effects?
Since this trial involves speech-language therapy, there aren't typical medical side effects; however, participants may experience fatigue or frustration during intensive therapy sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am not participating in any other speech therapy during this study.
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It's been 6 months since my stroke, which caused speech issues.
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I can do daily tasks by myself or have someone to help me.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I had a stroke in the right side of my brain.
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I have a neurological condition that is not a stroke.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~(1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and (1) 1 week prior to intervention; (2) immediately prior to intervention; (3) 1-2 days post intervention (4) 8 to 12 weeks post intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Confrontation Naming
Secondary study objectives
Aphasia Communication Outcome Measure (ACOM)
Comprehensive Aphasia Test
Magnetic Resonance Imaging
+3 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: SFA Experimental InterventionExperimental Treatment1 Intervention
A modified version of Semantic Feature Analysis will be administered.
Group II: SFA Active Comparator InterventionActive Control1 Intervention
A standard version of Semantic Feature Analysis will be administered.

Find a Location

Logistics

Travel, including flights, are covered

Your expenses for travel tickets for this trial will be reimbursed.

Who is running the clinical trial?

VA Pittsburgh Healthcare SystemLead Sponsor
34 Previous Clinical Trials
13,186 Total Patients Enrolled
Penn State UniversityOTHER
370 Previous Clinical Trials
127,965 Total Patients Enrolled
1 Trials studying Aphasia
19 Patients Enrolled for Aphasia
William D Hula, Ph.D.Principal InvestigatorVA Pittsburgh Healthcare System
Patrick J Doyle, Ph.D.Principal InvestigatorVA Pittsburgh Healthcare System

Media Library

Semantic Feature Analysis Treatment Clinical Trial Eligibility Overview. Trial Name: NCT04215952 — N/A
Aphasia Research Study Groups: SFA Experimental Intervention, SFA Active Comparator Intervention
Aphasia Clinical Trial 2023: Semantic Feature Analysis Treatment Highlights & Side Effects. Trial Name: NCT04215952 — N/A
Semantic Feature Analysis Treatment 2023 Treatment Timeline for Medical Study. Trial Name: NCT04215952 — N/A
~5 spots leftby Aug 2025