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Procedure

tACS for Aphasia

N/A
Recruiting
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Presence of aphasia
Suffered a single, left hemisphere stroke
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5-10 minutes after a single session of active (alpha tacs) and sham (fake tacs).

Summary

This trial tests if tACS can improve language skills in post-stroke aphasia, and see if it is different to aged matched controls.

Who is the study for?
This trial is for right-handed individuals who have had a stroke in the left hemisphere of their brain at least 6 months ago and are now experiencing aphasia, which affects language abilities. They must understand the study and agree to participate.
What is being tested?
Researchers are testing if active transcranial alternating current stimulation (tACS) can improve language skills in people with post-stroke aphasia. Participants will undergo real and sham tACS while performing language tests to measure effectiveness.
What are the potential side effects?
Potential side effects of tACS may include mild discomfort or skin irritation at the electrode sites, headache, fatigue, or transient dizziness. These side effects are generally considered minimal.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have difficulty with speaking or understanding language.
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I had one stroke on the left side of my brain.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5-10 minutes after a single session of active (alpha tacs) and sham (fake tacs).
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5-10 minutes after a single session of active (alpha tacs) and sham (fake tacs). for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Performance on the Blocked-Cyclic Naming (BCN) Task

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: real-tACSActive Control1 Intervention
The active stimulation will consist of an alternating current delivered in the alpha frequency band with a peak-to-peak intensity of 4 milliamps (mA) for 20 minutes. Participants will complete sentence completion and verb generation task during stimulation.
Group II: sham-tACSPlacebo Group1 Intervention
Sham stimulation involves the delivery of 60 seconds of the actual stimulation waveform ("ramp up") which is then gradually reduced to 0 milliamps (mA) ("ramp down"). Participants will complete sentence completion and verb generation task during stimulation.

Find a Location

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,084 Previous Clinical Trials
42,726,928 Total Patients Enrolled
31 Trials studying Stroke
4,643 Patients Enrolled for Stroke
~80 spots leftby Aug 2028