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Broccoli Sprouts, then Alfalfa Sprouts for Allergy

N/A
Waitlist Available
Led By Elizabeth C Matsui, MD MHS
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights

Summary

Sulforaphane (SFN) is a naturally occurring isothiocyanate that is a potent inducer of Phase II enzymes which play a critical role in preventing oxidative stress (via activation of Nrf2). Broccoli sprouts (BS) contain the richest source of SFN. The main objectives of this study are to test the effect of broccoli sprouts (BS) on biomarkers of oxidative stress (OS), inflammation, basophil activation, and clinical outcomes in mouse allergen-induced asthma by (1) determining if BS improves lung function and airways symptom responses in mouse-sensitized adults with asthma undergoing environmental mouse allergen challenge (EMAC), (2) examining the effect of BS on OS, inflammation, and basophil activation, and (3) examining the effect of BS on changes in OS, inflammation, and basophil activation after EMAC.

Eligible Conditions
  • Allergy
  • Asthma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Forced Expiratory Volume at One Second (FEV1)

Trial Design

2Treatment groups
Experimental Treatment
Group I: Broccoli Sprouts, then Alfalfa SproutsExperimental Treatment2 Interventions
Broccoli Sprout sandwich/wrap will be eaten daily for 7 consecutive days followed by alfalfa sprouts after washout.
Group II: Alfalfa Sprouts, then Broccoli SproutsExperimental Treatment2 Interventions
Alfalfa Sprout sandwich/wrap will be eaten daily for 7 consecutive days followed by broccoli sprouts after washout.

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalOTHER
3,000 Previous Clinical Trials
13,308,398 Total Patients Enrolled
National Institute of Environmental Health Sciences (NIEHS)NIH
290 Previous Clinical Trials
1,232,956 Total Patients Enrolled
Johns Hopkins UniversityLead Sponsor
2,316 Previous Clinical Trials
14,872,822 Total Patients Enrolled
~0 spots leftby Oct 2025
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