What side effects are associated with this type of intervention?

The most common treatments for light sensitivity using diagnostic tools such as facial feature analysis, pupil responses, retinal electrical responses, and autonomic nerve responses to light are generally non-invasive and well-tolerated. Potential side effects may include transient discomfort or irritation from light exposure during testing, and occasionally mild headaches or eye strain.

What prior FDA approvals exist?

The FDA has approved various treatments for light sensitivity, often related to underlying conditions such as migraines or certain eye disorders. These treatments include medications like triptans for migraines, which can reduce light sensitivity as a symptom, and specialized lenses or glasses designed to filter specific wavelengths of light. Additionally, some treatments focus on managing the root causes of light sensitivity, such as anti-inflammatory drugs for uveitis. While the trial mentioned involves advanced diagnostic tools like objective measurement of facial features, pupil responses, retinal electrical responses, and autonomic nerve responses to light, specific FDA-approved treatments directly targeting these diagnostic methods are not detailed in the provided context.

What other types of research exist?

Promising novel alternatives for diagnosing and monitoring light sensitivity in 2024 include advanced imaging techniques such as Optical Coherence Tomography (OCT) for detailed retinal analysis, portable brain-computer interfaces for objective assessment of visual function loss, and enhanced photic stimulation tests to evaluate autonomic nerve responses. These technologies offer non-invasive, precise, and comprehensive diagnostic capabilities that can aid in the effective management of light sensitivity.

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Diagnostic Monitoring Techniques for Light Sensitivity

N/A

Recruiting

Research Sponsored by Randy Kardon

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18-80

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 day

Awards & highlights

No Placebo-Only Group

Summary

This trial uses tools to measure how a person's face, eyes, and nerves react to light. It targets people with light sensitivity and headaches, including those with traumatic brain injuries and migraines. By understanding these reactions, doctors aim to develop better treatments for these conditions.

Who is the study for?

This trial is for healthy individuals aged 18-80 who have had a normal eye exam in the past year. It's designed to help those with traumatic brain injury and associated light sensitivity or migraines by objectively measuring their response to light.

What is being tested?

The study tests new methods like videography, ocular coherence tomography (OCT), wrist-watch sensor devices, pupillography, and electrophysiology to diagnose and monitor treatment of light sensitivity and headaches in patients.

What are the potential side effects?

Since this trial involves diagnostic tools rather than medications, traditional side effects are not expected. However, participants may experience discomfort from bright lights or wearing sensors.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 80 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 day

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Correlation of facial responses to light sensitivity

Difference in objective biological markers of light sensitivity between light sensitive and normal subjects

Secondary study objectives

Correlation of objective biological marker of light sensitivity to macula (structure found in the back of the eye).

Correlation of objective biological marker of light sensitivity to optic nerve structures

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

5Treatment groups

Active Control

Group I: TBI patients with photosensitivityActive Control5 Interventions

Group II: TBI Patients without photosensitivityActive Control5 Interventions

Group III: Migraine patients without photosensitivityActive Control5 Interventions

Group IV: Migraine patients with photosensitivityActive Control5 Interventions

Group V: Healthy Control subjectsActive Control5 Interventions

0 / 1Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for light sensitivity often involve the use of diagnostic tools that measure facial features, pupil responses, retinal electrical responses, and autonomic nerve responses to light. These tools help in objectively assessing the physiological reactions to light exposure, which is essential for accurate diagnosis and effective treatment planning. By understanding these mechanisms, healthcare providers can develop personalized treatment strategies that address the specific triggers and symptoms of light sensitivity, ultimately improving patient outcomes and quality of life.

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