Exercise for Breast Cancer
Recruiting in Palo Alto (17 mi)
+1 other location
Age: 18+
Sex: Female
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Dana-Farber Cancer Institute
Must not be taking: Investigational agents
Disqualifiers: Uncontrolled illness, Active malignancies, Metastatic disease, others
No Placebo Group
Trial Summary
What is the purpose of this trial?The purpose of this research is to determine whether a 16-week exercise program for individuals with breast cancer and have completed treatment (i.e., surgery, chemotherapy, or radiation) for breast cancer will decrease inflammation in fat tissue.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, you can continue using adjuvant endocrine therapy, trastuzumab, or pertuzumab if you will be on them for the duration of the study.
What data supports the effectiveness of the treatment CARE, CARE+COACH, Home-Based Stretching, Home-Based Stretching Program, Home-Based Exercise Program, Stretching Therapy for breast cancer?
Research suggests that home-based exercise programs can be beneficial for breast cancer survivors, helping them stick to their exercise routines and improve their long-term health. Additionally, physical activity, including stretching and exercise, has been shown to enhance quality of life and emotional well-being in cancer survivors.
12345Is the exercise program safe for participants?
Research suggests that home-based exercise programs are generally safe and beneficial for health, including for cancer survivors and older adults, as they can improve physical functioning and quality of life.
36789How is the CARE home-based exercise treatment for breast cancer unique?
The CARE home-based exercise treatment is unique because it allows breast cancer survivors to perform exercises at home, which can improve long-term compliance and health benefits. This approach is particularly beneficial for enhancing shoulder mobility and quality of life after surgery, offering a flexible and accessible alternative to traditional in-person therapy sessions.
12101112Eligibility Criteria
This trial is for women over 18 with breast cancer who've finished treatment, are in remission, and meet specific health criteria like a BMI >30. They must not have other uncontrolled illnesses or be on certain treatments. Participants should exercise less than 60 minutes per week and agree to use contraception.Inclusion Criteria
I have had surgery to remove a breast lump or the entire breast.
I do not have chronic diseases like uncontrolled diabetes, high blood pressure, or thyroid issues.
My breast cancer is in remission with no signs of disease.
+15 more
Exclusion Criteria
You are currently a smoker.
I am not currently on any experimental treatments or other cancer therapies.
You do not have excessive fat around your waist.
+9 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants undergo a 16-week exercise program involving either circuit-style or traditional aerobic and resistance exercises
16 weeks
7 testing visits, 48 exercise training visits
Follow-up
Participants are monitored for safety and effectiveness after treatment
8 months
Participant Groups
The study tests if a 16-week exercise program can reduce inflammation in fat tissue of breast cancer survivors. It involves TARE (Targeted Radiotherapy), Home-Based Stretching, and CARE (Comprehensive Assessment and Response Evaluation).
3Treatment groups
Experimental Treatment
Active Control
Group I: Traditional Aerobic Resistance Exercise (TARE)Experimental Treatment1 Intervention
This research study involves exercise. Participants in this study will be assigned to one of 2 exercise groups, undergo three (voluntary) biopsies of fat tissue, and participate in 7 testing visits and 48 exercise training visits. Participation is expected to last 12 months
- 16 weeks of traditional aerobic and resistance exercise
Group II: Circuit-style aerobic and resistance Exercise(CARE)Experimental Treatment1 Intervention
This research study involves exercise. Participants in this study will be assigned to one of 2 exercise groups, undergo three (voluntary) biopsies of fat tissue, and participate in 7 testing visits and 48 exercise training visits. Participation is expected to last 12 months.
-16 weeks of circuit-style aerobic and resistance exercise
Group III: Home-Based StretchingActive Control1 Intervention
Attention Control for 16 weeks home-based stretching
-structured home-based stretching program, participants will be asked to maintain their current activity level for the 4-month study duration, and will be offered the CARE program upon study completion
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Brigham and Women's HospitalBoston, MA
Dana Farber Cancer InstituteBoston, MA
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Who Is Running the Clinical Trial?
Dana-Farber Cancer InstituteLead Sponsor
National Cancer Institute (NCI)Collaborator
References
Effectiveness of a Home-Based Exercise Intervention in the Fitness Profile of Hispanic Survivors of Breast Cancer. [2022]Home-based exercise interventions might be a desirable long-term option for breast cancer survivors to enhance compliance and long-term health benefits.
Physical therapy and dance in the surgical management of breast cancer. A clinical report. [2019]This report describes a creative therapeutic exercise program that is part of a preoperative and postoperative regimen prescribed for patients with breast cancer surgery. Since August 1982, physical therapy has been offered as part of a multidisciplinary breast cancer program at our acute-care hospital. Our physical therapy department provides preoperative and postoperative evaluations and treatment for patients with breast cancer surgery. This treatment is offered on an outpatient basis and includes group dance sessions that are supervised by a licensed physical therapist and a licensed dance teacher. Physical therapy for patients with breast cancer surgery need not be limited to traditional wall-climbing exercises. Early physical therapy intervention should be directed at the unique emotional and physical problems encountered by these patients. Through dance, patients may experience the freedom of total body movement that enhances their adjustment to a new body image. An organized group setting provides a support mechanism that enables patients to share their experiences, fosters a positive attitude toward exercise, and facilitates psychological adjustment to the diagnosis of breast cancer.
Community-Based Exercise Programs for Cancer Survivors: A Scoping Review of Program Characteristics Using the Consolidated Framework for Implementation Research. [2022]To describe the characteristics of exercise programs for survivors of cancer conducted outside of a research laboratory (ie, home-based or community-based settings).
Supports and Barriers to Home-Based Physical Activity During Preoperative Treatment of Pancreatic Cancer: A Mixed-Methods Study. [2023]Physical activity and exercise appear to benefit patients receiving preoperative treatment for cancer. Supports and barriers must be considered to increase compliance with home-based exercise prescriptions in this setting. Such influences have not been previously examined.
Peer mentorship to promote physical activity among cancer survivors: effects on quality of life. [2022]Physical activity (PA) adoption can improve quality of life (QOL) and related outcomes among breast cancer survivors. To disseminate a telephone-based PA intervention to cancer survivors, we partnered with the American Cancer Society's Reach To Recovery program (RTR) whose volunteers (breast cancer survivors) provide information and emotional support to breast cancer survivors.
Feasibility of implementing the Strong for Life program in community settings. [2019]We describe the results of the dissemination of an efficacious, home-based exercise program called Strong for Life as it was implemented in a nationwide, volunteer caregiving program called Faith in Action, including training of volunteers who implemented the program, recruitment of older adult participants, exercise adherence, and attitudes and perceptions of program staff and participants.
Community-based exercise for health promotion and secondary cancer prevention in Canada: protocol for a hybrid effectiveness-implementation study. [2023]Cancer care has expanded from a disease-focused, survival-oriented model to an approach that now considers how survivors can live well in the aftermath of intensive therapy, where they may deal with significant changes to their bodies, mental health or emotional well-being. Research evidence supports the benefit of exercise during and following cancer treatments for cancer-related symptoms, physical functioning and fitness, and health-related quality of life. To move this efficacy evidence into practice, we designed and launched a 5-year study to evaluate the relative benefit from implementing a clinic-to-community-based cancer and exercise model of care.
Variability and limitations in home-based exercise program descriptions in oncology: a scoping review. [2020]The literature reflects considerable heterogeneity in what constitutes home-based exercise interventions. The variability for where and what "home-based" exercise can represent challenges interpretation of findings and appropriate advocacy, referral, or development of these models of care. Therefore, the objective of this review was to provide a comprehensive summary of how home-based exercise is defined and reported in the literature and summarize the range of supportive elements utilized in home-based exercise trials.
Home-Based Indoor Physical Activity Programs for Community-Dwelling Older Adults: A Systematic Review. [2023]Home-based exercise programs are a good strategy to promote benefits to health for people who cannot visit gyms, clinics, or have limited time for physical activity outside.
Telerehabilitation and Monitoring Physical Activity in Patient with Breast Cancer: Systematic Review. [2022]Timely rehabilitation in patients with Breast Cancer (BC) has a great impact on improving their physical and mental conditions. Thus, the appropriate follow-up method is essential especially during the Covid-19 pandemic. The aim of this study was to review the different technology-assisted interventions for improving physical activity in BC patients.
Exercise for the Patient after Breast Cancer Surgery. [2018]To describe how mobilization stretches and exercise decrease shoulder impairments, a complication related to breast cancer surgery, thus improving quality of life.
The Cardiac Rehabilitation Model Improves Fitness, Quality of Life, and Depression in Breast Cancer Survivors. [2019]Exercise is a demonstrated, therapeutic strategy for cancer survivors to minimize many treatment-induced side effects and may decrease risk of recurrence. Nonetheless, structured programs that combine exercise and education are not yet standardized within cancer care. The Health, Exercise, Active Living, Therapeutic lifestyle (HEALTh) program is a clinical exercise program based on the established cardiac rehabilitation model, but customized for female breast cancer survivors. This study assessed the effects of a cardiac rehabilitation program on cardiorespiratory fitness, quality of life, and depressive symptoms in breast cancer survivors.