Optical Imaging for Gum Disease
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Massachusetts General Hospital
Disqualifiers: Eye diseases, Eye surgeries, Diabetes, others
No Placebo Group
Trial Summary
What is the purpose of this trial?The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Optical Imaging for Gum Disease?
Research shows that Optical Coherence Tomography (OCT) can effectively image and monitor gum disease by providing detailed images of the tissues in the mouth. It has been used to track improvements in gum health after treatment, making it a useful tool for diagnosing and following up on periodontal disease.
12345Is optical imaging for gum disease safe for humans?
Optical imaging techniques like Optical Coherence Tomography (OCT) are generally considered safe for humans as they are non-invasive and do not use harmful radiation, making them suitable for imaging oral tissues.
35678How does the optical imaging treatment for gum disease differ from other treatments?
Optical imaging for gum disease uses optical coherence tomography (OCT), a noninvasive method that provides detailed images of oral tissues without the need for X-rays or biopsies. This treatment is unique because it allows for real-time monitoring and early detection of periodontal disease by capturing high-resolution images of both hard and soft tissues in the mouth.
235910Eligibility Criteria
This trial is for people aged 18-75 with healthy eyes. It's designed to test a new imaging technique on various tissues, including gums, skin, and corneas.Inclusion Criteria
I am between 18 and 75 years old with healthy eyes.
I am between 18 and 75 years old with healthy skin.
I am between 18 and 75 years old with healthy gums.
+1 more
Exclusion Criteria
I have had eye diseases or surgeries in the past.
I have diabetes or a family history of glaucoma.
Group 1: Subjects allergic to anesthetic eyedrop, especially proparacaine
+6 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Imaging
Optical imaging of the cornea, skin, and gingiva in healthy subjects and cornea in keratoconus subjects
1 year
Follow-up
Participants are monitored for safety and effectiveness after imaging procedures
4 weeks
Participant Groups
The study is testing OCT Vibrography (OCT elastography), an optical imaging method that measures how stiff or elastic human tissues are without needing surgery.
4Treatment groups
Experimental Treatment
Group I: Keratoconus corneaExperimental Treatment1 Intervention
Optical imaging of the cornea in mild and moderate keratoconus
Group II: Healthy skinExperimental Treatment1 Intervention
Optical imaging of the skin in healthy subjects
Group III: Healthy gingivaExperimental Treatment1 Intervention
Optical imaging of the gingiva in healthy subjects
Group IV: Healthy corneaExperimental Treatment1 Intervention
Optical imaging of the cornea in healthy subjects
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Massachusetts General HospitalBoston, MA
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Who Is Running the Clinical Trial?
Massachusetts General HospitalLead Sponsor
Massachusetts Eye and Ear InfirmaryCollaborator
References
Optical coherence tomography follow-up of patients treated from periodontal disease. [2020]Optical coherence tomography (OCT) is one of the most important imaging modalities for biophotonics applications. In this work, an important step towards the clinical use of OCT in dental practice is reported, by following-up patients treated from periodontal disease (PD). A total of 147 vestibular dental sites from 14 patients diagnosed with PD were evaluated prior and after treatment, using a swept-source OCT and two periodontal probes (Florida probe and North Carolina) for comparison. The evaluation was performed at four stages: day 0, day 30, day 60 and day 90. Exceptionally one patient was evaluated 1-year after treatment. It was possible to visualize in the two-dimensional images the architectural components that compose the periodontal anatomy, and identify the improvements in biofilm and dental calculus upon treatment. In the follow-up after the treatment, it was observed in some cases decrease of the gingival thickness associated with extinction of gingival calculus. In some cases, the improvement of both depth of probing with the traditional probes and the evidence in the images of the region was emphasized. The study evidenced the ability of OCT in the identification of periodontal structures and alterations, being an important noninvasive complement or even alternative for periodontal probes for treatment follow-up. OCT system being used in a clinical environment. Above OCT image (left) prior treatment and (right) 30 days after treatment.
Tissue characterization using optical coherence tomography and cone beam computed tomography: a comparative pilot study. [2017]To evaluate the ability of optical coherence tomography (OCT) in differentiating human oral tissues in comparison with cone beam computed tomography.
Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography. [2022]We have developed a prototype optical coherence tomography (OCT) system for the imaging of hard and soft tissue in the oral cavity. High-resolution images of in vitro porcine periodontal tissues have been obtained with this system. The images clearly show the enamel-cementum and the gingiva-tooth interfaces, indicating OCT is a potentially useful technique for diagnosis of periodontal diseases. To our knowledge, this is the first application of OCT for imaging biologic hard tissue.
Observation and determination of periodontal tissue profile using optical coherence tomography. [2018]Diagnosis is a crucial step in periodontal treatment. The aim of this study was to evaluate the effectiveness of optical coherence tomography (OCT) for observation and determination of periodontal tissue profiles in vivo.
Optical coherence tomography diagnostic imaging. [2008]Optical coherence tomography (OCT) is a noninvasive and nondestructive method for imaging the microstructural detail of oral tissue in situ, providing clinicians with quantitative and qualitative information. It is capable of evaluating the health of hard and soft tissue by providing a cross-sectional "optical biopsy" of tissue up to 3 mm in depth from the surface. The resultant imaging has an axial resolution of 1-10 micro, capturing structural details not possible with x-rays (and without the use of ionizing radiation). OCT imaging has the potential to detect and diagnose very early stages of disease in teeth, periodontal tissue, and mucosa. Early demineralization, remineralization, recurrent caries, tooth and restorative failures, root canals, periodontal disease, soft tissue dysplasias, and precancerous lesions can be imaged and monitored in real time on a computer monitor.
Structural validation of oral mucosal tissue using optical coherence tomography. [2021]Optical coherence tomography (OCT) is a non-invasive optical technology using near-infrared light to produce cross-sectional tissue images with lateral resolution.
In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: preliminary studies in 50 patients. [2021]In vivo, non-invasive optical coherence tomography (OCT) permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies.
In Vivo Endoscopic Optical Coherence Tomography of the Healthy Human Oral Mucosa: Qualitative and Quantitative Image Analysis. [2020]To date, there is still a lack of reliable imaging modalities to improve the quality of consultation, diagnostic and medical examinations of the oral mucosa in dentistry. Even though, optical technologies have become an important element for the detection and treatment of different diseases of soft tissue, for the case of oral screenings the evidence of the benefit in comparison to conventional histopathology is mostly still pending. One promising optical technology for oral diagnostics is optical coherence tomography (OCT). To prove the potential of OCT, even the amount of freely accessible OCT data is not sufficient to describe the variance of healthy human oral soft tissue in vivo. In order to remedy this deficiency, the present study provides in vivo OCT cross sections of the human oral mucosa of the anterior and posterior oral cavity as well as the oropharynx of 47 adult volunteers. A collection of representative OCT cross sections forms the basis for a randomized blinded image analysis by means of seven criteria to assess the main features of the superficial layers of the human oral mucosa and to determine its correlation to regional features known from hematoxylin and eosin (HE) stained histology.
The Use of Optical Coherence Tomography in Dental Diagnostics: A State-of-the-Art Review. [2023]Optical coherence tomography provides sections of tissues in a noncontact and noninvasive manner. The device measures the time delay and intensity of the light scattered or reflected from biological tissues, which results in tomographic imaging of their internal structure. This is achieved by scanning tissues at a resolution ranging from 1 to 15 μm. OCT enables real-time in situ imaging of tissues without the need for biopsy, histological procedures, or the use of X-rays, so it can be used in many fields of medicine. Its properties are not only particularly used in ophthalmology, in the diagnosis of all layers of the retina, but also increasingly in cardiology, gastroenterology, pulmonology, oncology, and dermatology. The basic properties of OCT, that is, noninvasiveness and low wattage of the used light, have also been appreciated in analytical technology by conservators, who use it to identify the quality and age of paintings, ceramics, or glass. Recently, the OCT technique of visualization is being tested in different fields of dentistry, which is depicted in the article.
Dental optical coherence tomography. [2021]This review paper describes the applications of dental optical coherence tomography (OCT) in oral tissue images, caries, periodontal disease and oral cancer. The background of OCT, including basic theory, system setup, light sources, spatial resolution and system limitations, is provided. The comparisons between OCT and other clinical oral diagnostic methods are also discussed.