CT vs PET Scans for Coronary Artery Disease

N/A

Recruiting

Led By Carlo De Cecco, MD, PhD

Research Sponsored by Emory University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

Currently taking or has taken within 48 hours the following excluded medications: ActoPlus Met (Pioglitazone + metformin), Avandamet (Rosiglitazone + metformin), Fortamet (metformin), Glucovance (Glyburide +metformin), Glucophage (metformin), Glucophage extended-release (XR) (metformin), Glumetza (metformin), Janumet (Sitagliptin + metformin), Metformin, Metaglip (Glipizide + metformin), Riomet (metformin), Implanted rhythm devices (pacemaker, defibrillator), Acute psychiatric disorder, Unwilling to comply with the requirements of the protocol, Previously entered this study, Known hypersensitivity to iodinated contrast material, beta-blockers, or pharmaceutical stressors used in this study, Suffers from claustrophobia, Impaired renal function (GFR < 45 ml/min), Acute hypotension (<100 mm Hg systolic), 2nd or 3rd degree atrioventricular (AV) block

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 1 (day of scans)

Awards & highlights

No Placebo-Only Group

Summary

This trial is comparing two different ways of measuring heart function: one using CT scans and one using PET scans. The goal is to see if CT scans are as accurate as PET scans.

Who is the study for?

This trial is for individuals who need a CT scan to check for coronary artery disease and are willing to follow the study's procedures. They must not be pregnant, nursing, or have taken certain diabetes medications recently. People with implanted heart devices, severe allergies to contrast material used in scans, kidney issues, low blood pressure, or specific heart rhythm problems cannot participate.

What is being tested?

The MATCH Investigation aims to compare two types of heart imaging tests: CT scans that measure blood flow and blockages in the heart arteries (CT-MPI and CT-FFR) against PET scans known as PET-MPI which is considered the gold standard.

What are the potential side effects?

Possible side effects include allergic reactions to contrast dye or stress agents used during imaging like Regadenoson. There might also be discomfort from lying still during scanning and exposure to radiation typical of medical imaging.