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Diagnostic Imaging for Coronary Heart Disease (SWAN Trial)

N/A
Waitlist Available
Led By Harmony Reynolds, M.D.
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Women with positive cardiac markers and/or ST elevation scheduled for angiography
Be older than 18 years old
Must not have
Prior diagnosis of obstructive CAD
Use of vasospastic agent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial will help doctors understand why some women have heart attacks even when they don't have any major blockages in their heart arteries.

Who is the study for?
This trial is for women who have had a heart attack or unstable angina and are scheduled for an angiography, but do not have major blockages in their heart arteries. Women with previous obstructive coronary artery disease, those who can't undergo IVUS or MRI procedures, or those using vasospastic agents cannot participate.
What is being tested?
The study uses intravascular ultrasound (IVUS) to take pictures of the inside of arteries and magnetic resonance imaging (MRI) to assess blood flow and damage in the heart. It aims to understand why some women experience heart attacks despite having no significant blockage in their arteries.
What are the potential side effects?
While this study does not involve drugs that could cause typical medication side effects, IVUS and MRI are generally safe but may include risks such as discomfort during the procedure, allergic reactions to contrast materials used, or complications from lying still during MRI.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am a woman with heart issues scheduled for a heart vessel check.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have been diagnosed with blocked arteries in my heart.
Select...
I am taking medication for blood vessel spasms.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: WomenExperimental Treatment2 Interventions
IVUS and MRI performed in women with no obstructive CAD at angiography
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MRI
2009
Completed Phase 2
~2810
Intravascular ultrasound
2007
N/A
~160

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,409 Previous Clinical Trials
855,765 Total Patients Enrolled
1 Trials studying Acute Coronary Syndrome
714 Patients Enrolled for Acute Coronary Syndrome
Doris Duke Charitable FoundationOTHER
64 Previous Clinical Trials
264,360 Total Patients Enrolled
Harmony Reynolds, M.D.Principal InvestigatorNYU Langone Health

Media Library

Intravascular ultrasound Clinical Trial Eligibility Overview. Trial Name: NCT00798122 — N/A
Acute Coronary Syndrome Research Study Groups: Women
Acute Coronary Syndrome Clinical Trial 2023: Intravascular ultrasound Highlights & Side Effects. Trial Name: NCT00798122 — N/A
Intravascular ultrasound 2023 Treatment Timeline for Medical Study. Trial Name: NCT00798122 — N/A
~3 spots leftby Nov 2025
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