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IPD Probe for Gut Permeability

N/A

Waitlist Available

Led By Guillermo Tearney, M.D, PhD.

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subject must be 18 to 60 years of age

Be between 18 and 65 years old

Must not have

Subjects with suspected or diagnosed Galactosemia

Subjects with a history of or being on medications that delay gastric emptying

Timeline

Screening 3 weeks

Treatment Varies

Follow Up imaging data is collected during the procedure, and analyzed within 1 year of collection.

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether a trans-nasal IPD probe can be used to measure gut permeability.

Who is the study for?

This trial is for healthy adults aged 18-60 who can consent and fast for at least 8 hours. It's not suitable for those with respiratory diseases, nasal steroid use, gastric emptying delays, alcoholism, certain medication uses (like clotting impairments or mast cell stabilizers), recent antibiotics use, liver diseases, galactosemia, uncontrolled diabetes, lactation due to pregnancy or any contraindications to nasopharyngeal procedures.

What is being tested?

The study is testing the feasibility of a trans-nasal IPD probe as a tool to measure gut permeability. Participants will undergo this minimally invasive procedure where the probe is inserted through the nose to assess intestinal function.

What are the potential side effects?

Potential side effects may include discomfort from the nasal insertion of the probe and possible irritation in the nose or throat. There might also be risks associated with fasting and reactions specific to individual health conditions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 60 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have been diagnosed with or suspected to have Galactosemia.

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I am on medication that slows down my stomach emptying.

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I am currently taking medication for heartburn or ulcers.

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I don't have conditions that prevent NJ tube placement like a deviated septum or sinus issues.

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I am taking medication that affects blood clotting or have a history of bleeding disorders.

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I use nasal or other steroids for my allergies.

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My diabetes is not under control.

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I am currently taking medication to stabilize mast cells.

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I have had surgery on my upper digestive tract.

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I have or might have hepatitis B or C.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ imaging data is collected during the procedure, and analyzed within 1 year of collection.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~imaging data is collected during the procedure, and analyzed within 1 year of collection.

This trial's timeline: 3 weeks for screening, Varies for treatment, and imaging data is collected during the procedure, and analyzed within 1 year of collection. for reporting.