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Behavioral Activation for Depression

New York, NY
Phase 2
Recruiting
Led By Rebecca Saracino, PhD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 months post intervention
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing if a type of therapy called behavioral activation, which helps people do enjoyable activities to feel better, can be done over the phone or video calls. It focuses on older adults who have survived cancer and are dealing with depression. Behavioral activation is a well-established treatment for depression, recognized for its effectiveness in increasing engagement in enjoyable activities to improve mood.

See full description
Who is the study for?
This trial is for older adults (65+) who have survived cancer, are experiencing mild to moderate depression, and can communicate via phone or video. They must be fluent in English and not require a higher level of psychiatric care. Those with major untreated psychotic disorders or recent changes in antidepressant medication use are excluded.
What is being tested?
The study tests if behavioral activation therapy, delivered remotely through telephone or videoconference, helps reduce depression in older adult cancer survivors compared to supportive psychotherapy.See study design
What are the potential side effects?
Since the interventions involve psychological therapies rather than medications, side effects may include emotional discomfort during sessions but typically do not involve physical side effects.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 months post intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 months post intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Difference of Patient Health Questionnaire 9 (PHQ-9) scores between study groups

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Older Adult Cancer Survivors (OACS) - Supportive Psychotherapy (SP)Experimental Treatment1 Intervention
Older adult cancer survivors (OACS) will receive a Supportive Psychotherapy intervention
Group II: Older Adult Cancer Survivors (OACS) - Behavioral Activation (BA)Experimental Treatment1 Intervention
Older adult cancer survivors (OACS) will receive a Behavioral Activation intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Behavioral Activation
2013
Completed Phase 3
~2900
Supportive Psychotherapy
2008
N/A
~1260

Find a Location

Closest Location:Memorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,997 Previous Clinical Trials
602,317 Total Patients Enrolled
Rebecca Saracino, PhDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

Media Library

Behavioral Activation Clinical Trial Eligibility Overview. Trial Name: NCT05574127 — Phase 2
Survivorship Research Study Groups: Older Adult Cancer Survivors (OACS) - Supportive Psychotherapy (SP), Older Adult Cancer Survivors (OACS) - Behavioral Activation (BA)
Survivorship Clinical Trial 2023: Behavioral Activation Highlights & Side Effects. Trial Name: NCT05574127 — Phase 2
Behavioral Activation 2023 Treatment Timeline for Medical Study. Trial Name: NCT05574127 — Phase 2
~6 spots leftby Jun 2025
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