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Diuretic

Active Therapy for Nephrogenic Diabetes Insipidus

N/A
Waitlist Available
Led By Melissa A Cadnapaphornchai, MD
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4-days
Awards & highlights

Summary

The purpose of this research study is to determine if two investigational medications will be more effective in decreasing urine output than the currently available and routinely used medications in patients with congenital nephrogenic diabetes insipidus (NDI).

Eligible Conditions
  • Nephrogenic Diabetes Insipidus

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4-days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4-days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
24h Urine Volume

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active TherapyExperimental Treatment4 Interventions
4-day treatment with hydrochlorothiazide/amiloride, indomethacin, calcitonin, sildenafil
Group II: Placebo ControlPlacebo Group4 Interventions
4-day treatment with hydrochlorothiazide/amiloride, indomethacin, placebo for calcitonin, placebo for sildenafil
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Indomethacin
FDA approved
Salmon calcitonin
FDA approved
Sildenafil
FDA approved
Amiloride
FDA approved

Find a Location

Who is running the clinical trial?

University of AarhusOTHER
1,375 Previous Clinical Trials
14,423,947 Total Patients Enrolled
University of Colorado, DenverLead Sponsor
1,758 Previous Clinical Trials
2,166,256 Total Patients Enrolled
Melissa A Cadnapaphornchai, MDPrincipal InvestigatorUniversity of Colorado, Denver
1 Previous Clinical Trials
110 Total Patients Enrolled
~0 spots leftby Jul 2025
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