Trial Summary
What is the purpose of this trial?The goal of this 16-week clinical trial is to assess the health benefits of a low-fat vegan diet on insulin sensitivity and glycemic control in type 2 diabetes. Participants will receive at no cost, study-related weekly nutrition education classes and one-on-one consultation with a registered dietitian.
Is the Low-fat Vegan Diet a promising treatment for Type 2 Diabetes?Yes, the Low-fat Vegan Diet is a promising treatment for Type 2 Diabetes. It helps improve diabetes management by reducing weight, blood sugar levels, and bad cholesterol more effectively than some other diets.12468
What safety data exists for a low-fat vegan diet in treating type 2 diabetes?The studies indicate that a low-fat vegan diet can improve diabetes management, glycemic control, and cardiovascular risk factors in individuals with type 2 diabetes. It is generally considered effective and nutritionally adequate, with practical considerations such as medication adjustment and risk of hypoglycemia being reviewed. However, specific safety data is not detailed in the provided abstracts.34568
What data supports the idea that Low-fat Vegan Diet for Type 2 Diabetes is an effective treatment?The available research shows that a low-fat vegan diet can be an effective treatment for type 2 diabetes. One study found that this diet improves blood sugar control and reduces risk factors for heart disease. Another study indicated that plant-based diets, which include low-fat vegan diets, help lower body weight, improve blood sugar levels, and reduce cholesterol more effectively than portion-controlled diets. These findings suggest that a low-fat vegan diet can be a beneficial option for managing type 2 diabetes.34678
Do I have to stop taking my current medications for the trial?The trial protocol does not specify if you need to stop taking your current medications. However, your medications must have been stable for the past 3 months, and you must be able to maintain your current medication regimen during the study.
Eligibility Criteria
Adults with type 2 diabetes, BMI of 26-40, stable medication use for the past 3 months, and HbA1c levels between 6.5-10.5% can join this trial. Excluded are those using recreational drugs or smoking recently, pregnant women or those planning pregnancy, individuals with unstable health conditions or eating disorders, non-English speakers, heavy drinkers, and anyone already on a low-fat vegan diet.Inclusion Criteria
I have type 2 diabetes and am treated with diet or pills, but not sulfonylureas.
My medications for diabetes, high blood pressure, and cholesterol have been the same for the last 3 months.
I am 18 years old or older.
Exclusion Criteria
I have a condition like thyroid disease that affects my weight.
I do not have any unstable medical or mental health conditions.
I have type 1 diabetes or I'm treated with insulin or sulfonylureas.
I am not fluent in English.
Treatment Details
This study tests how a low-fat vegan diet affects insulin sensitivity and blood sugar control in type 2 diabetes over a period of 16 weeks. Participants will receive free nutrition education classes and consultations with dietitians to help them follow the dietary plan.
1Treatment groups
Experimental Treatment
Group I: Intervention Group: low-fat vegan dietExperimental Treatment1 Intervention
This arm of participants will be asked to attend weekly online classes in nutrition and health and to follow a low-fat, vegan diet for 16 weeks.
Find a clinic near you
Research locations nearbySelect from list below to view details:
Physicians Committee for Responsible MedicineWashington, United States
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Who is running the clinical trial?
Physicians Committee for Responsible MedicineLead Sponsor
Yale UniversityCollaborator
References
Toward improved management of NIDDM: A randomized, controlled, pilot intervention using a lowfat, vegetarian diet. [2022]To investigate whether glycemic and lipid control in patients with non-insulin-dependent diabetes (NIDDM) can be significantly improved using a low-fat, vegetarian (vegan) diet in the absence of recommendations regarding exercise or other lifestyle changes.
[Diabetic diet 2000]. [2015]Diabetes diet in the year 2000 consists essentially of carbohydrates. 50% to 60% of the total caloric intake has to be taken in form of carbohydrate. Slowly metabolised forms of carbohydrate should be preferred. Fat and proteins should not exceed more than 20% of the respective total caloric intake. Vegetable fats should be preferred compared to animal fats. Patients with type 2 diabetes who should loose weight have to be extremely careful regarding the fat intake. Insulin-dependent diabetics can correct mistakes in the carbohydrate intake by injecting fast insulins provided that they have in-depth knowledge of the mode of action of insulin and dietary experience.
A low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes. [2022]We sought to investigate whether a low-fat vegan diet improves glycemic control and cardiovascular risk factors in individuals with type 2 diabetes.
Changes in nutrient intake and dietary quality among participants with type 2 diabetes following a low-fat vegan diet or a conventional diabetes diet for 22 weeks. [2022]Although vegan diets improve diabetes management, little is known about the nutrient profiles or diet quality of individuals with type 2 diabetes who adopt a vegan diet.
A plant-based diet for type 2 diabetes: scientific support and practical strategies. [2020]The purpose of this review is to provide educators with the knowledge and tools to utilize plant-based nutrition education as an intervention for type 2 diabetes. Scientific support for the efficacy, acceptability, and nutritional adequacy of a plant-based diet for people with type 2 diabetes is presented, and practical considerations such as medication adjustment and risk of hypoglycemia are reviewed.
Turning the Waiting Room into a Classroom: Weekly Classes Using a Vegan or a Portion-Controlled Eating Plan Improve Diabetes Control in a Randomized Translational Study. [2022]In research settings, plant-based (vegan) eating plans improve diabetes management, typically reducing weight, glycemia, and low-density lipoprotein (LDL) cholesterol concentrations to a greater extent than has been shown with portion-controlled eating plans.
Perspective: Plant-Based Eating Pattern for Type 2 Diabetes Prevention and Treatment: Efficacy, Mechanisms, and Practical Considerations. [2023]A plant-based eating pattern is associated with a reduced risk of developing type 2 diabetes and is highly effective in its treatment. Diets that emphasize whole grains, vegetables, fruits, and legumes and exclude animal products improve blood glucose concentrations, body weight, plasma lipid concentrations, and blood pressure and play an important role in reducing the risk of cardiovascular and microvascular complications. This article reviews scientific evidence on the effects of plant-based diets for the prevention and treatment of type 2 diabetes. The mechanisms by which plant-based diets improve body weight, insulin sensitivity, and β-cell function are described. Practical considerations including education, nutrition adequacy, and adjusting medications will enhance the success of patients who have diabetes.
Low-carbohydrate vegan diets in diabetes for weight loss and sustainability: a randomized controlled trial. [2023]Low-carbohydrate, high animal fat and protein diets have been promoted for weight loss and diabetes treatment. We therefore tested the effect of a low-carbohydrate vegan diet in diabetes as a potentially healthier and more ecologically sustainable low-carbohydrate option.