Deep Brain Stimulation for Spasmodic Dysphonia and Tremor
Trial Summary
What is the purpose of this trial?
This trial studies how Deep Brain Stimulation (DBS) affects voice control in patients with dystonia and essential tremor. DBS sends electrical impulses to brain areas that manage movement, aiming to improve voice function in these patients. Deep Brain Stimulation (DBS) has been used to treat severe movement disorders, including Parkinson's disease, dystonia, and essential tremor.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Deep Brain Stimulation for Spasmodic Dysphonia and Tremor?
Research shows that Deep Brain Stimulation (DBS) can improve symptoms of spasmodic dysphonia (a voice disorder) and tremor. In a study, patients with both conditions experienced significant improvement, especially with stimulation on one side of the brain. This suggests DBS could be a promising treatment for these voice and movement disorders.12345
Is Deep Brain Stimulation generally safe for humans?
Deep Brain Stimulation (DBS) has been used for various movement disorders like Parkinson's disease, but it can have complications such as infections, lead migrations, and device malfunctions. Some patients may experience neurobehavioral effects, and in certain cases, serious complications like cerebral bleeds or device-related trauma may occur, requiring further surgery.678910
How is the treatment Deep Brain Stimulation (DBS) different from other treatments for spasmodic dysphonia?
Deep Brain Stimulation (DBS) is unique because it involves implanting electrodes in the brain to modulate neural circuits, offering a potentially long-lasting improvement for spasmodic dysphonia without the need for repeated injections like botulinum toxin A (BTX). Unlike BTX, which requires regular administration, DBS can provide continuous symptom relief and may address underlying neural pathways involved in the condition.12111213
Eligibility Criteria
This trial is for adults aged 18-80 with voice disorders due to dystonia or essential tremor, who are candidates for deep brain stimulation (DBS) surgery. Participants must be able to follow instructions, complete training, and give informed consent. They should not have obstructive venous anatomy, significant hearing loss, or inability to perform required tasks.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Surgery and Data Collection
Electrophysiological data collection during DBS surgery for patients with dystonia or tremor
Follow-up
Participants are monitored for changes in voice and motor function using clinical rating scales
Treatment Details
Interventions
- Deep Brain Stimulation (Procedure)
Deep Brain Stimulation is already approved in United States, European Union, Canada for the following indications:
- Essential tremor
- Parkinson's disease
- Dystonia
- Obsessive-compulsive disorder
- Epilepsy
- Chronic pain
- Stroke-related motor deficits (under investigation)
- Essential tremor
- Parkinson's disease
- Dystonia
- Obsessive-compulsive disorder
- Epilepsy
- Chronic pain
- Essential tremor
- Parkinson's disease
- Dystonia
- Obsessive-compulsive disorder
- Epilepsy
- Chronic pain