← Back to Search

AMAB + continuous estrogen for Cardiovascular Disease

N/A
Recruiting
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0.5 hours
Awards & highlights

Summary

The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults who were assigned male at birth. Participants will: give one blood draw of 5 mL have a camera placed under the tongue to take pictures of blood vessels have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion Researchers will compare blood vessel function of those who take estrogen supplements to those who do not.

Eligible Conditions
  • Cardiovascular Disease
  • Estrogen
  • Microvasculature

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0.5 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0.5 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Perfused Vessel Density
Change in blood vessel dilation

Trial Design

2Treatment groups
Experimental Treatment
Group I: AMAB - continuous estrogenExperimental Treatment3 Interventions
Identify as assigned male at birth (AMAB) who have not had continuous estrogen treatment for a minimum of 1 year.
Group II: AMAB + continuous estrogenExperimental Treatment3 Interventions
Identify as assigned male at birth (AMAB) who have had continuous estrogen treatment for a minimum of 1 year.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Acetylcholine
2013
Completed Phase 2
~220
Sodium Nitroprusside
2018
Completed Phase 1
~240

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor
614 Previous Clinical Trials
1,162,859 Total Patients Enrolled
~13 spots leftby Dec 2029
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top