Study to Determine if Taking OTC Non-Steroidal Anti-Inflammatory Affects Eye Pressure in Patients Using Glaucoma Drops

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byJoseph I. Markoff, Ph.D,M.D

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Philadelphia Eye Associates

No Placebo Group

Trial Summary

What is the purpose of this trial?The Purpose of This Study is to Determine if Taking an Over the Counter Non-Steroidal Anti-Inflammatory(Ibuprofen)has an Effect on Eye Pressure in Patients using Brimonidine(Alphagan)and Latanoprost(Xalatan) eye drops.

Eligibility Criteria

Inclusion Criteria

Patients with bilateral or unilateral primary open angle glaucoma or ocular hypertension

An IOP in each eye of greater than 22mm HG after washout of IOP lowering medications

No worse than 20/200 best corrected visual acuity

+3 more

Participant Groups

3Treatment groups

Active Control

Group I: LatanoprostActive Control2 Interventions

to determine whether commonly used OTC non-steroidal anti-inflammatory agents taken orally has any effect on the ability of either latanoprost or brimonidine to lower high eye pressure

Group II: BrimonidineActive Control2 Interventions

to determine whether commonly used OTC non-steroidal anti-inflammatory agents taken orally has any effect on the ability of either latanoprost or brimonidine to lower high eye pressure

Group III: ibuprofenActive Control2 Interventions

to determine whether commonly used OTC non-steroidal anti-inflammatory agents taken orally has any effect on the ability of either latanoprost or brimonidine to lower high eye pressure

Brimonidine is already approved in United States, European Union, Canada for the following indications:

🇺🇸 Approved in United States as Alphagan for: