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Cognitive Training for Post-Transplant Cognitive Impairment (cTAG Trial)

N/A
Recruiting
Led By Noha M Sharafeldin
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
History of color blindness
History of pre-existing neurological disorder or documented major psychiatric disorder; significant auditory, visual, or motor impairments
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights
No Placebo-Only Group

Summary

This trial will test whether it is possible to enroll patients in a study to improve their thinking skills after they have had a hematopoietic cell transplant, as well as whether patients are interested in learning about their genetic risk for cognitive impairment after the transplant.

Who is the study for?
This trial is for adults over 21 who had a bone marrow transplant at UAB, are 3-6 months post-transplant, and can use an internet-connected computer. It's not for those with neurological or major psychiatric disorders, significant sensory/motor issues, color blindness, or recent neuropsychological intervention.
What is being tested?
The study tests if the Lumosity cognitive training program helps improve brain function in people who've had a bone marrow transplant. Participants will either start training right away or be placed on a waitlist (control group) to compare results.
What are the potential side effects?
Since this trial involves cognitive exercises using Lumosity rather than medication, traditional side effects like you'd see with drugs aren't expected. However, participants may experience fatigue or frustration.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have a history of color blindness.
Select...
I do not have a major neurological or psychiatric disorder, or significant hearing, vision, or movement issues.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in cognitive function between intervention and wait list control arms from baseline to 12 weeks.
Number of HCT patients completing the 2-arm wait-listed randomized trial of cognitive training intervention for a period of 3 months
Secondary study objectives
16-item survey to measure genetic factual knowledge at baseline
5 Likert scale survey questionnaire to measure impact of receiving genetic risk information on intervention adherence
5 Likert scale survey questionnaire to measure impact of receiving genetic risk information on intervention uptake
+2 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: InterventionExperimental Treatment1 Intervention
The arm will begin the Lumosity program at enrollment in the study.
Group II: Wait List ControlActive Control1 Intervention
The arm will begin the Lumosity program 3 months after enrollment in the study.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Lumosity
2016
N/A
~50

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,646 Previous Clinical Trials
2,342,324 Total Patients Enrolled
Noha M SharafeldinPrincipal InvestigatorUniversity of Alabama at Birmingham

Media Library

Lumosity Clinical Trial Eligibility Overview. Trial Name: NCT03094026 — N/A
Blood Cancers Research Study Groups: Intervention, Wait List Control
Blood Cancers Clinical Trial 2023: Lumosity Highlights & Side Effects. Trial Name: NCT03094026 — N/A
Lumosity 2023 Treatment Timeline for Medical Study. Trial Name: NCT03094026 — N/A
~4 spots leftby Jul 2025
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