K-Talk Intervention for HPV Vaccination

Recruiting in Palo Alto (17 mi)

Overseen by Minjin Kim, PhD., RN

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: University of Cincinnati

Disqualifiers: Non-Korean, Outside U.S., Age, others

No Placebo Group

Approved in 1 Jurisdiction

Trial Summary

What is the purpose of this trial?

The goal of this clinical trial is to test the feasibility, acceptability, and preliminary efficacy of a storytelling video-based intervention using AI chatbot technology (K-Talk) to promote HPV vaccination behavior among Korean Americans aged 18 to 45. The main questions this study aims to answer are: * Is the K-Talk intervention feasible for use among Korean Americans aged 18 to 45? * Is the K-Talk intervention acceptable to the target population? * What is the preliminary efficacy of the K-Talk intervention in promoting HPV vaccination uptake? Participants will be Korean Americans aged 18 to 45 who are at risk for HPV infection. Participants will be asked to complete a baseline survey and then will be "randomized" into one of four groups: Group 1 (chatbot + storytelling intervention), Group 2 (chatbot only), Group 3 (storytelling only), and Group 4 will be only exposed to written didactic HPV education materials. All groups will receive written didactic HPV education materials. Researchers will compare how Group 1, a combination of AI Chatbot and storytelling intervention is more effective than other intervention groups in promoting HPV vaccination uptake among underserved, hard-to-reach Korean Americans.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It seems focused on promoting HPV vaccination through educational interventions, so it's unlikely that your current medications will be affected.

What data supports the effectiveness of the K-Talk Intervention for HPV Vaccination?

Research shows that using conversational agents (like chatbots) for HPV vaccine counseling can positively impact beliefs about the vaccine and improve its uptake. Additionally, storytelling video interventions have been found to significantly increase the likelihood of getting the HPV vaccine, especially in specific groups like Korean American college women.

^{1 2 3 4 5}

Is the K-Talk Intervention for HPV Vaccination safe for humans?

The studies on the K-Talk Intervention, which uses conversational agents and storytelling videos for HPV vaccine counseling, show that participants found these tools easy to use and effective in improving their knowledge and attitudes towards the HPV vaccine. There are no reported safety concerns in the available research.

^{1 2 3 5 6}

How is the K-Talk Intervention treatment for HPV vaccination different from other treatments?

The K-Talk Intervention is unique because it uses storytelling videos and an AI chatbot to educate and encourage people to get the HPV vaccine, making it more engaging and interactive compared to traditional information-based methods.

^{1 2 4 7 8}

Eligibility Criteria

This trial is for Korean Americans aged 18 to 26 who live in the U.S., speak or read English, have not received an HPV vaccine, and use a mobile device. It's designed to see if a video and chatbot program can increase HPV vaccination rates.

Inclusion Criteria

Identify as a Korean ethnic person

Reside in the U.S.

Be able to speak or read English

Exclusion Criteria

Participants who do not identify as a Korean ethnic person

Participants who do not reside in the U.S.

Participants who cannot speak or read English

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

1 week

Online eligibility screening survey

Baseline Assessment

Participants complete a baseline survey and are randomized into intervention groups

1 week

Online survey

Intervention

Participants receive their assigned intervention (chatbot, storytelling, or both) for 3 months

3 months

Weekly interactions via web-based platform or email

Follow-up

Participants are monitored for HPV vaccination uptake and knowledge assessment

12 months

Follow-up surveys at 3, 6, and 12 months

Participant Groups

The study tests K-Talk, which combines storytelling videos and AI chatbot technology to encourage HPV vaccinations. Participants are split into four groups: one with both chatbot and storytelling, one with just the chatbot, one with only storytelling, and one receiving written information.

Group I: Storytelling Intervention Experimental Treatment 2 Interventions

After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The storytelling intervention group will only be exposed to periodic release of stories via email for 3 months.

Group II: K-Talk Intervention: Storytelling and AI Chatbot Experimental Treatment 2 Interventions

After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The K-Talk group will receive a series of weekly storytelling videos, and access to the chatbot via the web-based platform KakaoTalk for 3 months.

Group III: K-Bot (AI Chatbot Intervention) Intervention Experimental Treatment 2 Interventions

After completing the pre-test survey, participants from all intervention groups will receive the written information. Subsequently, they will be randomly assigned to one of the intervention groups. The K-Bot group will only interact with the chatbot via the web-based platform or KakaoTalk for 3 months.

Group IV: Written Information Active Control 1 Intervention

This group will only be exposed to written, didactic HPV education materials after the pre-test.

K-Talk Intervention is already approved in United States for the following indications:

🇺🇸 Approved in United States as K-Talk for:

• Promotion of HPV vaccination behavior among Korean Americans aged 18 to 45

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Minjin Kim Cincinnati, OH

Who Is Running the Clinical Trial?

University of Cincinnati Lead Sponsor

References

1. United States pubmed.ncbi.nlm.nih.gov

Examining Potential Usability and Health Beliefs Among Young Adults Using a Conversational Agent for HPV Vaccine Counseling. [2020] The human papillomavirus (HPV) vaccine is the most effective way to prevent HPV-related cancers. Integrating provider vaccine counseling is crucial to improving HPV vaccine completion rates. Automating the counseling experience through a conversational agent could help improve HPV vaccine coverage and reduce the burden of vaccine counseling for providers. In a previous study, we tested a simulated conversational agent that provided HPV vaccine counseling for parents using the Wizard of OZ protocol. In the current study, we assessed the conversational agent among young college adults (n=24), a population that may have missed the HPV vaccine during their adolescence when vaccination is recommended. We also administered surveys for system and voice usability, and for health beliefs concerning the HPV vaccine. Participants perceived the agent to have high usability that is slightly better or equivalent to other voice interactive interfaces, and there is some evidence that the agent impacted their beliefs concerning the harms, uncertainty, and risk denials for the HPV vaccine. Overall, this study demonstrates the potential for conversational agents to be an impactful tool for health promotion endeavors.

2. United States pubmed.ncbi.nlm.nih.gov

A Storytelling Intervention in a Mobile, Web-Based Platform: A Pilot Randomized Controlled Trial to Evaluate the Preliminary Effectiveness to Promote Human Papillomavirus Vaccination in Korean American College Women. [2022] Korean American women have substantially greater incidence rates of cervical cancer and the lowest rates of cervical cancer screening in the United States. However, there has been minimal research to promote human papillomavirus (HPV) vaccination among this population. A pilot randomized controlled trial was conducted to evaluate preliminary effectiveness of a storytelling video intervention using mobile, Web-based technology. One hundred and four Korean American college women were randomized to the experimental group (storytelling video) or the comparison group (information-based written material). The effects of the intervention were assessed immediately postintervention and at the 2-month follow-up. Both groups improved in knowledge of and attitude toward the HPV vaccine at the postintervention. At the 2-month follow-up, the experimental group was twice as likely to receive the HPV vaccine compared to the comparison group. This preliminary evidence supports the use of a storytelling video intervention and shows substantial promise for further development and testing in larger scale studies.

3. United States pubmed.ncbi.nlm.nih.gov

Announcements Versus Conversations to Improve HPV Vaccination Coverage: A Randomized Trial. [2022] Improving provider recommendations is critical to addressing low human papillomavirus (HPV) vaccination coverage. Thus, we sought to determine the effectiveness of training providers to improve their recommendations using either presumptive "announcements" or participatory "conversations."

4. Ireland pubmed.ncbi.nlm.nih.gov

Communication technologies to improve HPV vaccination initiation and completion: A systematic review. [2022] This systematic review examines the effectiveness of communication technology interventions on HPV vaccination initiation and completion.

5. Netherlands pubmed.ncbi.nlm.nih.gov

Early Usability Assessment of a Conversational Agent for HPV Vaccination. [2020] With the emerging use of speech technology in consumer goods, we experimented with the application of conversational agents for the communication of health information relating to HPV vaccine. Research have stated that one-to-one contact between providers and patients have a variety of positive influences on patients' perception towards vaccines, even leading to uptake, compared to paper-based methods. We implemented a Wizard of Oz experiment that counsels adults with children (n=18) on the HPV vaccine, using an iPad tablet and dialogue script developed by public health collaborators, and for early testing of a prospective conversational agent in this area. Our early results show that non-vaccine hesitant parents believed that agent was easy to use and had capabilities needed, despite the desire for additional features. Our future work will involve developing a dialogue engine to provide automated dialogue interaction and future improvements and experimentation for the speech interface.

6. Canada pubmed.ncbi.nlm.nih.gov

Developing a Culturally and Linguistically Congruent Digital Storytelling Intervention in Vietnamese and Korean American Mothers of Human Papillomavirus-Vaccinated Children: Feasibility and Acceptability Study. [2023] The high morbidity, mortality, and economic burden attributed to cancer-causing human papillomavirus (HPV) call for researchers to address this public health concern through HPV vaccination. Disparities of HPV-associated cancers in Vietnamese and Korean Americans exist, yet their vaccination rates remain low. Evidence points to the importance of developing culturally and linguistically congruent interventions to improve their HPV vaccination rates. We adopted digital storytelling (DST) that combines oral storytelling with computer-based technology (digital images, audio recording, and music) as a promising approach for facilitating the communication of culturally relevant health messages.

7. Canada pubmed.ncbi.nlm.nih.gov

Informing Content and Feature Design of a Parent-Focused Human Papillomavirus Vaccination Digital Behavior Change Intervention: Synchronous Text-Based Focus Group Study. [2022] Human papillomavirus (HPV) is a common and preventable sexually transmitted infection; however, vaccination rates in the United States among the target age group, which is 11-12 years, are lower than national goals. Interventions that address the barriers to and facilitators of vaccination are important for improving HPV vaccination rates. Web-based, text-based focus groups are becoming a promising method that may be well suited for conducting formative research to inform the design of digital behavior change intervention (DBCI) content and features that address HPV vaccination decision-making.

8. England pubmed.ncbi.nlm.nih.gov

"But can chatbots understand sex?" Attitudes towards artificial intelligence chatbots amongst sexual and reproductive health professionals: An exploratory mixed-methods study. [2023] Artificial Intelligence (AI)-enabled chatbots can offer anonymous education about sexual and reproductive health (SRH). Understanding chatbot acceptability and feasibility allows the identification of barriers to the design and implementation.