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Electrolyte

Salt Intake for High Blood Pressure Differences by Race

N/A

Recruiting

Led By Austin T Robinson, PhD

Research Sponsored by Indiana University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

BMI below 35 Kg/m2 (otherwise healthy)

Aged between 19-75

Must not have

History of cancer

History of cardiovascular disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline (pre-intervention)

Summary

This trial will test if salt affects blood pressure differently in black vs white people, and if lifestyle factors play a role in these differences.

Who is the study for?

This trial is for non-smoking individuals aged 19-75 with a BMI below 35 and no history of metabolic, pulmonary, or cardiovascular diseases. Participants must have blood pressure under 150/90 mmHg and be free from conditions that limit exercise or blood donation.

What is being tested?

The study investigates how dietary salt affects blood vessel function and blood pressure regulation differently in black versus white individuals. It also examines the impact of lifestyle factors like sleep, physical activity, and nutrition on these racial differences.

What are the potential side effects?

Since this trial involves acute salt intake as an intervention, potential side effects may include increased thirst, swelling due to fluid retention (edema), elevated blood pressure levels, and strain on the heart or kidneys.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My BMI is under 35.

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I am between 19 and 75 years old.

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I do not have diabetes, kidney disease, lung problems, or heart and blood vessel diseases.

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I have not smoked or used tobacco in the last year.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had cancer in the past.

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I have a history of heart disease.

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I have a history of diabetes.

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I have a history of kidney disease.

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My BMI is over 30.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ before, 30 minutes, and one hour after soup, both conditions (high- and low- salt)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~before, 30 minutes, and one hour after soup, both conditions (high- and low- salt)

This trial's timeline: 3 weeks for screening, Varies for treatment, and before, 30 minutes, and one hour after soup, both conditions (high- and low- salt) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Changes in blood biomarkers of nitric oxide bioavailability

Changes in blood pressure reactivity

Changes in circulating inflammatory cytokines

+3 more

Secondary study objectives

Cardiorespiratory fitness

Habitual dietary intake

Mental health - depression

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: High Sodium Meal (2500 mg sodium)Experimental Treatment1 Intervention

Participants will have sympathetic nerve activity, vascular function, blood pressure and blood samples (from intravenous catheters) assessed before and after a high sodium meal (2500 mg sodium).

Group II: Low Sodium Meal (140 mg sodium)Placebo Group1 Intervention

Participants will have sympathetic nerve activity, vascular function, blood pressure and blood samples (from intravenous catheters) assessed before and after a low sodium meal (140 mg sodium) which will serve as the control condition to demonstrate whether or not observed changes are due to high sodium or occur irrespective of sodium in the postprandial state.

0 / 9Eligibility criteria met