~13 spots leftby Apr 2026

Confocal Endomicroscopy During Endoscopy

Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: University of Alberta
No Placebo Group

Trial Summary

What is the purpose of this trial?

The main objective of this study is to determine the role of epithelial cell homeostasis in the pathogenesis of intestinal diseases. Background: Alterations in intestinal barrier function may play a significant role in the pathogenesis of chronic intestinal diseases such as inflammatory bowel disease (IBD). The intestinal epithelium functions as a barrier to the luminal contents, thereby preventing undesirable solutes, micro-organisms and other luminal antigens from entering the body. Confocal endomicroscopy has recently been shown that increased epithelial cell shedding may contribute to increased intestinal permeability, at least locally. In our study, we want to determine the contribution of epithelial cell shedding to intestinal permeability in vivo in patients with inflammatory bowel disease compared to controls. Scope: In inflammatory bowel disease patients and controls (patients undergoing endoscopy for other indications). Methods: We will perform confocal endoscopy during the patient's endoscopic procedure. Procedure: The patient will receive intravenous fluorescein, followed by confocal imaging of the gastrointestinal tissue. The images are captured on the computer. The proposed study will provide important insights into epithelial cell shedding as a contributor to altered intestinal permeability.

Research Team

Eligibility Criteria

Inclusion Criteria

Subjects over 18 years of age.
Subjects undergoing endoscopic procedures such as gastroscopy, colonoscopy, endoscopic retrograde cholangiopancreatography and endoscopic ultrasound will all be included.

Treatment Details

Interventions

  • Confocal Endomicroscopy (Procedure)
Participant Groups
2Treatment groups
Experimental Treatment
Group I: Diseased groupExperimental Treatment1 Intervention
Patients with Crohn's disease or ulcerative colitis undergoing endoscopy.
Group II: ControlExperimental Treatment1 Intervention
In patients undergoing endoscopy for indications other than Crohn's disease or ulcerative colitis

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
University of AlbertaEdmonton, Canada
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Who Is Running the Clinical Trial?

University of Alberta

Lead Sponsor

Trials
957
Patients Recruited
437,000+