Obesity and Oxalate Production in Kidney Stones

Recruiting in Palo Alto (17 mi)

Overseen byKyle D Wood, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Alabama at Birmingham

No Placebo Group

Trial Summary

What is the purpose of this trial?

The goal of this study is to determine if obesity is associated with increased endogenous oxalate synthesis as assessed by urinary oxalate excretion, which is a known risk factor for calcium oxalate kidney stones. The study will recruit adult participants without history of kidney stones. Participants will * Ingest fixed diets containing low amounts of oxalate for 4 days * Collect 24-hr urine samples during the fixed diet

Eligibility Criteria

This trial is for adults with a BMI under 30 who have had kidney stones made mostly of calcium oxalate, and those with Type 2 Diabetes showing specific blood sugar levels. It's not for pregnant individuals, people with abnormal urine or blood tests that could affect the study results, anyone with poor kidney function (GFR < 60), or a BMI over 32.

Inclusion Criteria

I have passed or had removed a kidney stone that is mostly made of calcium oxalate.

Your body mass index (BMI) is less than 30.

I have type 2 diabetes with high blood sugar or A1c levels.

Exclusion Criteria

Your urine or blood tests show unusual chemical or metabolic levels.

My kidney function is reduced, with a GFR under 60.

Pregnancy

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Treatment Details

Interventions

Obesity Management (Other)

Trial OverviewThe study aims to understand how obesity affects urinary oxalate levels and the formation of calcium oxalate kidney stones. It will explore this link in different groups: non-obese individuals, obese stone formers, and diabetics.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Normal IndividualsExperimental Treatment1 Intervention

Normal individuals: no prior history of kidney stones