What side effects are associated with this type of intervention?

Common treatments for Patellofemoral Pain Syndrome (PFPS) often include strength training and power exercises, similar to those in the STRIPE Program. Known side effects of these treatments can include muscle soreness, fatigue, and, in some cases, temporary increases in pain due to the physical stress placed on the muscles and joints. Overuse injuries, such as tendinitis, may also occur if exercises are not performed with proper technique or if there is insufficient rest between sessions. It is important for patients to follow a well-structured program and consult with healthcare professionals to minimize these risks.

What prior FDA approvals exist?

There are no specific FDA-approved drugs mentioned for the treatment of Patellofemoral Pain Syndrome (PFPS) in the provided context. The STRIPE program focuses on strength training and power exercises, which are non-pharmacologic interventions. Common treatments for PFPS typically include physical therapy, exercise programs targeting muscle strength and flexibility, and sometimes pain relief medications. The emphasis is often on rehabilitative and integrative therapies rather than pharmacologic treatments.

What other types of research exist?

Promising alternatives to the STRIPE program for PFPS patients include: 1) Eccentric exercise programs, which have shown effectiveness in reducing pain and improving function in tendinopathy conditions. 2) Progressive-resisted exercises, which have been beneficial in improving muscle strength and quality of life in related conditions. 3) Myofascial release and paradoxical relaxation training, which have been effective in chronic pain management. 4) Acupuncture, which has shown potential benefits in tendinopathy treatment. These alternatives can be discussed with a healthcare provider to tailor the best approach for individual patient needs.

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Strength vs Power Training for Patellofemoral Pain (STRIPE Trial)

Q: What is the mechanism of action of this treatment?

The most common treatments for Patellofemoral Pain Syndrome (PFPS) include strength training and power exercises. Strength training focuses on enhancing the strength of the quadriceps and hip muscles, which helps stabilize the patella and alleviate pain. Power exercises involve rapid, forceful movements that improve muscle power and neuromuscular control, further aiding in patellar stability. These treatments are essential for PFPS patients as they correct muscle imbalances and biomechanical issues, leading to reduced pain and improved functional outcomes.

N/A

Recruiting

Led By Neal Glaviano, PhD

Research Sponsored by University of Connecticut

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Participants to be between the ages of 18-40 years old.

Insidious onset of symptoms greater than 3 months.

Must not have

History of patella subluxation, meniscal injury or ligamentous instability.

History of lower extremity surgery.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.

Awards & highlights

No Placebo-Only Group

Summary

This trial tests a new exercise program called STRIPE for people with persistent knee pain. The program aims to build muscle strength and power to reduce pain and prevent it from coming back.

Who is the study for?

This trial is for people aged 18-40 with patellofemoral pain that started on its own over 3 months ago and hurts at least a bit during activities like sitting long, jumping, or climbing stairs. It's not for those with other knee issues, history of knee cap dislocation, meniscus or ligament injuries, leg surgery, or pain from the lower back.

What is being tested?

The study compares two 6-week rehab programs for knee pain: Standard of Care (SOC) vs. Strength Training with Power Exercises (STRIPE). It will check which program better reduces pain and prevents it from coming back while improving leg strength and squatting form.

What are the potential side effects?

While specific side effects aren't listed here, exercise-based rehab can sometimes lead to muscle soreness, joint discomfort or exacerbation of existing symptoms if not done correctly.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 18 and 40 years old.

Select...

My symptoms started slowly over more than 3 months ago.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have had issues with my kneecap, meniscus, or ligaments.

Select...

I have had surgery on my leg or foot.

Select...

I have experienced pain that spreads from my lower back.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~immediately after the intervention and then 6, 12, 18, and 24 months post-intervention.

This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately after the intervention and then 6, 12, 18, and 24 months post-intervention. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in hip adduction during a single leg squat

Change in hip rate of torque development

Change in knee pain.

+3 more

Secondary study objectives

Change in cognitive factors

Change in coping strategy

Change in physical activity

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Strength Training Rehabilitation Incorporating Power Exercises (STRIPE)Experimental Treatment1 Intervention

Those in the STRIPE group will complete two power and one strength training sessions a week. All participants will be provided an educational pamphlet and exercises will be divided into four components - hip abductors, hip extensors, core, and quadriceps muscles. The load magnitude will be greater than 60% of the 1RM, with the goal of continually loading against heavy resistance. Participants will complete 4 sets of 6 repetitions, with 3-5 minutes of rest between sets. Time under tension will be prescribed as \<1 second for the concentric phase and 1 second for the eccentric phase of the exercise. The strength training sessions will adhere to same parameters as the SOC. Hip abductor, hip extensor, and core exercises will be initiated during week 1 and continued for the 6-week intervention, while quadriceps focused exercises will be introduced in weeks 3-6.

Group II: Standard of Care (SOC)Active Control1 Intervention

The SOC rehabilitation group will complete three strength sessions a week. All participants will be provided an educational pamphlet and exercises will be divided into four components - hip abductors, hip extensors, core, and quadriceps muscles. The load magnitude for exercises will be between 60-70% of their 1 repetition max (1RM), with 3 sets of 12 repetitions and a 2-3-minute rest between sets. Time under tension will be prescribed as slow to moderate, with a 2-second concentric phase and 2-second eccentric phase for each exercise. Hip abductor, hip extensor, and core exercises will be initiated during week 1 and continued for the 6-week intervention, while quadriceps focused exercises will be introduced in weeks 3-6.

0 / 5Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

The most common treatments for Patellofemoral Pain Syndrome (PFPS) include strength training and power exercises. Strength training focuses on enhancing the strength of the quadriceps and hip muscles, which helps stabilize the patella and alleviate pain. Power exercises involve rapid, forceful movements that improve muscle power and neuromuscular control, further aiding in patellar stability. These treatments are essential for PFPS patients as they correct muscle imbalances and biomechanical issues, leading to reduced pain and improved functional outcomes.