Exercise for Chronic Kidney Disease
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of North Texas, Denton, TX
Approved in 1 Jurisdiction
Trial Summary
What is the purpose of this trial?The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).
Do I have to stop taking my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What data supports the idea that Exercise for Chronic Kidney Disease is an effective treatment?
The available research shows that exercise can significantly improve the quality of life for people with chronic kidney disease (CKD). It helps reduce inflammation, depression, and the need for hospitalization, while also improving nutrition and overall health. Exercise is beneficial at all stages of CKD and empowers patients to take control of their health. Additionally, a study involving a 12-week exercise program showed positive impacts on patients' physical abilities and quality of life, suggesting that exercise should be a key part of CKD care.
12345What safety data exists for exercise in chronic kidney disease treatment?
The safety of exercise in chronic kidney disease (CKD) has been evaluated in several studies. Exercise training has been shown to increase exercise capacity, improve muscle strength and function, decrease blood pressure, and improve inflammation and oxidative stress biomarkers. However, most studies are small, non-randomized, and non-controlled, and the effects on kidney function, cardiovascular disease, and quality of life are not well known. A single-armed interventional study in Japanese patients with stable CKD evaluated the effectiveness and safety of modest exercise, suggesting it is safe. More research is needed to develop evidence-based exercise guidelines for CKD patients.
678910Is exercise a promising treatment for chronic kidney disease?
Yes, exercise is a promising treatment for chronic kidney disease. It improves physical strength, endurance, and quality of life for patients at all stages of the disease. Exercise can also reduce healthcare costs and help patients feel more in control of their health.
311121314Eligibility Criteria
This trial is for people with moderate to severe chronic kidney disease (stages III-IV). It's not suitable for those with heart failure, lung issues like COPD, uncontrolled blood pressure problems, pregnant women or those planning pregnancy, and individuals already exercising regularly.Inclusion Criteria
I have moderate to severe kidney disease.
I have moderate to severe kidney disease.
Exclusion Criteria
Pregnancy or plans to become pregnant
I have chronic obstructive pulmonary disease.
You can't ride a stationary bike.
+3 more
Participant Groups
The study is looking at how regular exercise might help the brain control blood flow in patients with chronic kidney disease. Participants will engage in supervised exercise routines including cycling and stretching exercises.
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Exercise TrainingExperimental Treatment1 Intervention
Participants will exercise 3 times a week on a stationary bicycle. Exercise intensity will begin at low levels (50% of maximal heart rate reserve) and increase as tolerated to a maximum of 80% of maximal heart rate reserve. Exercise time will progress from an initial 20 minutes per session to a maximum of 45 minutes per session.
Group II: StretchingPlacebo Group1 Intervention
Participants will undergo progressive whole body stretching and balance exercises. This type of low intensity exercise is designed not to increase heart rate but rather to improve joint mobility and the ability to perform activities of daily living. This will serve as the control group to the exercise group. The control group will come in for stretching sessions 3 times per week for 20-45 minutes.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of North TexasDenton, TX
Loading ...
Who Is Running the Clinical Trial?
University of North Texas, Denton, TXLead Sponsor
References
Exercise as a therapeutic intervention in chronic kidney disease: are we nearly there yet? [2023]The opportunity to review the more recent evidence for prescribing exercise-based physical rehabilitation for people living with chronic kidney disease (CKD) is timely. There has been a recent global focus evaluating how physical activity interventions might improve health-related quality of life and outcomes for people living with chronic health conditions in a post-COVID era. There is finally a long overdue commitment from the kidney research and clinical community to deliver pragmatic interventions to help people living with CKD to be able to live well with their condition.
[Association of physical activity with quality of life in patients with chronic kidney disease]. [2021]Physical activity may improve quality of life in patients with chronic kidney disease.
The benefits of exercise for CKD patients. [2013]People with chronic kidney disease and end-stage renal disease often suffer from multiple related disorders, progressive deconditioning, and loss of functional capacity. Yet increased physical activity has been shown to improve patients' quality of life and nutrition, reduce inflammation and depression, and decrease treatment costs and the need for hospitalization. Exercise training should thus be considered an important part of the overall care of people with CKD, while increased physical activity is beneficial at all stages of the disease and can help empower patients to take more control over their own health.
Evaluation of a pragmatic exercise rehabilitation programme in chronic kidney disease. [2022]Physical activity has the potential to positively impact upon aerobic and functional ability, and the quality of life of all chronic kidney disease (CKD) patients independent of the stage of the disease process. Physical activity is recommended in a number of national CKD guidelines, but its incorporation into routine care has been slow. The translation of research-led physical activity programmes into an established procedure appears to be a particular obstacle. This study included 263 patients, consecutively referred over a 4-year period, to a pragmatic 12-week renal rehabilitation (RR) programme delivered within a National Health Service (NHS).
Effect of an exercise rehabilitation program on physical function over 1 year in chronic kidney disease: an observational study. [2022]Exercise rehabilitation may help maintain physical function in chronic kidney disease (CKD), but long-term clinical effectiveness is unknown. We evaluated the effect of an exercise rehabilitation program on physical function over 1 year in individuals with CKD.
Association of physical activity with mortality in chronic kidney disease. [2022]Chronic kidney disease (CKD) is an important risk factor for all-cause mortality. In the general population, physical activity is associated with reduced mortality. We examined the association of level of physical activity with mortality in patients with predominantly nondiabetic CKD stage 3-4.
Dose-response effects of physical activity on all-cause mortality and major cardiorenal outcomes in chronic kidney disease. [2022]Physical activity has a protective effect against mortality and cardiovascular events in chronic kidney disease (CKD) patients. Nonetheless, how different levels of physical activity affect the health benefits in CKD remains unclear. This study aimed to investigate the dose-response effects of physical activity on mortality and major cardiorenal events in CKD.
Moderate-Vigorous Physical Activity and Clinical Outcomes in Adults with Nondialysis Chronic Kidney Disease. [2023]The health benefits of physical activity (PA) are well known. However, the association between an adequate amount of moderate-vigorous PA (MVPA) and clinical outcomes has limited evidence in chronic kidney disease (CKD). We assessed PA using a self-administered questionnaire. The amount of MVPA was categorized into four groups: none, low, moderate, and high (0, <7.5, 7.5-14.9, and 15.0-29.9 metabolic equivalent-hours/week, respectively). We analyzed the association between the amount of MVPA and clinical outcomes. Among a total of 1909 adults with CKD, adults with MVPA showed various beneficial outcomes compared to those with no MVPA in a Kaplan-Meier curve followed over a median of 5.9 years. In multivariable-adjusted Cox proportional hazard models, a low and a moderate amount of MVPA was associated with a lower risk of all-cause death. A moderate amount of MVPA was associated with a lower risk of cardiovascular events. A high amount of MVPA was associated with a lower risk of end-stage kidney disease in ESKD in 1324 adults with eGFR <60 mL/min/1.73 m2. Age and sex modified the relationships between MVPA and clinical outcomes. MVPA is associated with various beneficial outcomes across the amount of MVPA. PA plans should be tailored for individual adults with CKD.
Exercise training in chronic kidney disease patients. [2022]Chronic kidney disease (CKD) is a major public health problem that affects an estimated 1.7 million Australians. Patients with CKD commonly progress to end-stage kidney disease (ESKD) requiring dialysis and/or kidney transplantation. They are at high risk of cardiovascular disease and many die from this prior to reaching ESKD. Few therapies are available to slow CKD progression and reduce cardiovascular morbidity and mortality. The benefit of exercise training has been well demonstrated in a range of disease conditions including ESKD and was recently highlighted by a systematic review in haemodialysis patients and a recent Cochrane review of all stages of CKD. However, the effects of exercise training in patients with CKD have not been extensively investigated. Our systematic search of the literature found only ten clinical trials in this area. The aim of this review is to review these studies, and to discuss the findings, safety considerations and suggest future areas of research. Overall, the majority of the studies are small, non-randomized, non-controlled trials. They have found that exercise training can increase exercise capacity, improve muscle strength and function, decrease blood pressure, and improve inflammation and oxidative stress biomarkers. The effects of exercise training on kidney function, cardiovascular disease and quality of life are unknown. Studies are needed to answer these questions and develop evidence-based exercise training guidelines for individuals with CKD.
The effectiveness and safety of modest exercise in Japanese patients with chronic kidney disease: a single-armed interventional study. [2022]Poor physical ability and skeletal muscle wasting are common in chronic kidney disease (CKD) patients, who may experience a decline in daily activity and, in turn, increased mortality. The purpose of this study was to evaluate the effectiveness and safety of modest exercise in patients with stable CKD.
[Physical working capacity and muscle strength in chronic renal failure are improved by exercise]. [2006]Patients with chronic kidney disease (CKD) show a decline in maximal exercise capacity and muscle strength as renal function decreases. Renal anaemia, skeletal muscle dysfunction, tiredness and increasing inactivity are the major causes of this deterioration. Exercise training improves maximal exercise capacity, muscle strength and endurance in young, middle-aged and elderly patients at all stages of CKD. Preferably exercise training should be started during the predialysis stage, however, it is equally effective in dialysis patients and after renal transplantation. It has a positive effect on muscle catabolism and counteracts weight loss and malnutrition. Moreover, exercise training has positive effects on functional capacity and health related quality of life. Exercise training should be prescribed by a neph-rologist and administered by a trained nephrological physiotherapist. Exercise training is an integral part of care of the CKD patient. It not only reduces suffering but also costs, resulting in major potential benefits for the patient, the health care system and society.
Exercise training in CKD: efficacy, adherence, and safety. [2022]Exercise training increasingly is recommended as an important part of the management of cardiovascular disease. However, few studies have evaluated the effectiveness of exercise training in patients with chronic kidney disease (CKD), and those that have included very selective populations.
Implementing exercise: what do we know? Where do we go? [2022]Exercise capacity, physical functioning, and physical activity are all low in patients with CKD treated with dialysis. Although there is robust evidence that these patients benefit from regular exercise training and/or increasing physical activity, the nephrology community has not adopted recommendations and encouragement for physical activity as a part of the routine care plan. This article reviews what is known regarding the implementation of exercise and provides suggestions as to how exercise counseling might become a routine part of the care of patients with CKD.
Exercise training in adults with CKD: a systematic review and meta-analysis. [2022]Whether exercise can affect health outcomes in people with chronic kidney disease (CKD) and what the optimal exercise strategies are for patients with CKD remain uncertain.