~12 spots leftby Dec 2025

Aging Assessment Tool for Cancer Patients

Recruiting in Palo Alto (17 mi)
RE
Overseen byRussell E Glasgow
Age: 65+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Colorado, Denver
Disqualifiers: Age < 65, Non-English/Spanish
No Placebo Group

Trial Summary

What is the purpose of this trial?

Aging is the greatest risk factor for cancer incidence and mortality. Geriatric screening is recommended to help with treatment discussions, inform intensity of treatment, and identify supportive care needs. Despite a strong evidence base, geriatric assessments are not implemented routinely in oncologic clinics. Similarly, important information on social determinants of health, mental health, and health behaviors are inconsistently assessed, and almost never in an integrated fashion. In an effort to support clinicians delivering the recommended goal-concordant care, the investigators will integrate assessment of geriatric issues, health behaviors, mental health, and social determinants of health into an efficient, actionable contextual assessment system for older cancer patients called Integrated Aging Assessment for Action for Cancer Patients (IA3-CP). The investigators will use D\&I strategies including co-creation engagement approaches and form-function methods to develop workflow processes that feasibly integrate the IA3-CP into usual initial assessment with the oncology team. Our objective is to develop and conduct a randomized pilot of the IA3-CP system and hypothesize that our results will show it can be implemented consistently, acted on, improve quality of care, and enhance patient-provider interactions.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Integrated Aging Assessment for Action for Cancer Patients (IA3-CP)?

The research highlights the importance of using geriatric assessments to better understand the health status of older cancer patients, which can help tailor treatments to improve outcomes like quality of life and functional independence. These assessments can identify factors beyond age that affect treatment success, suggesting that IA3-CP could be effective in optimizing cancer care for older adults.12345

Is the Aging Assessment Tool for Cancer Patients safe for humans?

The research highlights that older adults with cancer are at increased risk of treatment-related toxicities, but it does not provide specific safety data for the Aging Assessment Tool for Cancer Patients. It suggests that comprehensive assessments may help identify those at risk of adverse outcomes, but no direct safety information for the tool itself is available.26789

How is the IA3-CP treatment different from other treatments for cancer in older patients?

The IA3-CP treatment is unique because it uses a comprehensive geriatric assessment to tailor cancer care specifically for older patients, considering their functional age rather than just their chronological age. This approach helps identify medical, psychosocial, and functional issues, allowing for more personalized and effective treatment plans.1011121314

Research Team

RE

Russell E Glasgow

Principal Investigator

University of Colorado, Denver

Eligibility Criteria

This trial is for cancer patients aged 65 or older who speak English or Spanish and are attending their initial oncology visit. They must be willing to participate in all study activities. It's open to those with various cancers, including leukemia, multiple myeloma, kidney tumors, breast cancer, Hodgkin's lymphoma, prostate cancer, and bladder cancer.

Inclusion Criteria

I am 65 years old or older.
I am 65 years old or older.
Patient must agree to participate in all study-related activities
See 2 more

Exclusion Criteria

I am under 65 years old.
My primary language is neither English nor Spanish.

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Initial Assessment

Integration of geriatric issues, health behaviors, mental health, and social determinants of health into the IA3-CP system

12 weeks
Multiple visits (in-person and virtual)

Treatment

Participants receive feedback and care planning based on IA3-CP assessments

16 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

7 months

Treatment Details

Interventions

  • Integrated Aging Assessment for Action for Cancer Patients (IA3-CP) (Behavioural Intervention)
Trial OverviewThe trial tests an assessment tool called IA3-CP designed to integrate geriatric issues, health behaviors, mental health assessments along with social determinants of health (SDoH). Patients will either receive the IA3-CP with SDoH considerations or without them to see how well these tools can be implemented and improve care.
Participant Groups
3Treatment groups
Experimental Treatment
Active Control
Group I: IA3-CP with SDoHExperimental Treatment1 Intervention
Assess IA3-CP with SDoH and provide feedback (provider \& patient)
Group II: IA3-CP onlyExperimental Treatment1 Intervention
Assess IA3-CP only without added SDoH and provide feedback (provider \& patient)
Group III: Control - usual careActive Control1 Intervention
Usual care: Assess IA3-CP without providing the feedback report

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
University of Colorado HospitalAurora, CO
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Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials
1842
Patients Recruited
3,028,000+

National Cancer Institute (NCI)

Collaborator

Trials
14080
Patients Recruited
41,180,000+

Findings from Research

Developing a cancer-specific geriatric assessment: a feasibility study.Hurria, A., Gupta, S., Zauderer, M., et al.[2010]
Optimising Clinical Trial Design in Older Cancer Patients.Whelehan, S., Lynch, O., Treacy, N., et al.[2020]
Evaluating the older patient with cancer: understanding frailty and the geriatric assessment.Pal, SK., Katheria, V., Hurria, A.[2022]
Geriatric assessment for oncologists: rationale and future directions.Hurria, A., Lachs, MS., Cohen, HJ., et al.[2010]
Analysis of prognostic factors of comprehensive geriatric assessment and development of a clinical scoring system in elderly Asian patients with cancer.Kanesvaran, R., Li, H., Koo, KN., et al.[2022]
Medication risks in older patients (70 +) with cancer and their association with therapy-related toxicity.Ortland, I., Mendel Ott, M., Kowar, M., et al.[2022]
Risk Factors for Chemotherapy-Related Toxicity and Adverse Events in Elderly Thai Cancer Patients: A Prospective Study.Phaibulvatanapong, E., Srinonprasert, V., Ithimakin, S.[2018]
A frailty index developed from patient-reported geriatric assessments can effectively identify older adults with cancer who are at higher risk for worse overall survival, functional decline, and severe treatment-related toxicities, based on a study of 589 patients with a median age of 69.
Specifically, frail patients had a 1.83 times higher risk of mortality and were three times more likely to experience significant functional decline and severe non-hematologic toxicities compared to robust patients, highlighting the importance of assessing frailty in cancer treatment planning.
Patient-reported geriatric assessment-based frailty index among older adults with gastrointestinal malignancies.Giri, S., Al-Obaidi, M., Harmon, C., et al.[2023]
Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer.Hurria, A., Mohile, S., Gajra, A., et al.[2022]
Developing a comprehensive cancer specific geriatric assessment tool.Rao, S., Salins, N., Deodhar, J., et al.[2016]
Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions.Vallet-Regí, M., Manzano, M., Rodriguez-Mañas, L., et al.[2018]
Geriatric assessment in oncology practice.Hurria, A.[2021]
Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers: Review and Research Recommendations.Mandelblatt, JS., Ahles, TA., Lippman, ME., et al.[2023]
Chronological age alone is not a reliable indicator for making treatment decisions in older cancer patients, as it does not reflect their true physiological and functional status.
A comprehensive geriatric assessment can provide valuable insights into various aspects of an older patient's health, helping oncologists make more informed, personalized treatment decisions that consider the patient's overall well-being.
Functional versus chronological age: geriatric assessments to guide decision making in older patients with cancer.Soto-Perez-de-Celis, E., Li, D., Yuan, Y., et al.[2019]

References

Developing a cancer-specific geriatric assessment: a feasibility study. [2010]
Optimising Clinical Trial Design in Older Cancer Patients. [2020]
Evaluating the older patient with cancer: understanding frailty and the geriatric assessment. [2022]
Geriatric assessment for oncologists: rationale and future directions. [2010]
Analysis of prognostic factors of comprehensive geriatric assessment and development of a clinical scoring system in elderly Asian patients with cancer. [2022]
Medication risks in older patients (70 +) with cancer and their association with therapy-related toxicity. [2022]
Risk Factors for Chemotherapy-Related Toxicity and Adverse Events in Elderly Thai Cancer Patients: A Prospective Study. [2018]
Patient-reported geriatric assessment-based frailty index among older adults with gastrointestinal malignancies. [2023]
Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer. [2022]
Developing a comprehensive cancer specific geriatric assessment tool. [2016]
Management of Cancer in the Older Age Person: An Approach to Complex Medical Decisions. [2018]
12.United Statespubmed.ncbi.nlm.nih.gov
Geriatric assessment in oncology practice. [2021]
13.United Statespubmed.ncbi.nlm.nih.gov
Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers: Review and Research Recommendations. [2023]
Functional versus chronological age: geriatric assessments to guide decision making in older patients with cancer. [2019]