Viability Assessment Technology for Liver Transplantation

Recruiting in Palo Alto (17 mi)

Overseen byHeidi Yeh, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Massachusetts General Hospital

No Placebo Group

Trial Summary

What is the purpose of this trial?Machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable. However, there are no validated metrics to determine transplantability after machine perfusion. This study involves collecting biopsies from transplanted livers before and after implantation to correlate metabolite and gene expression with post-transplant function. This data will help develop a viability index for machine perfused livers.

Eligibility Criteria

This trial is for men and women aged 18-75 who are candidates for a liver transplant from a deceased donor. It's not open to individuals who test positive for HIV-1.

Inclusion Criteria

I am between 18 and 75 years old.

I am eligible for a liver transplant from a deceased donor.

I am between 18 and 75 years old.

+1 more

Exclusion Criteria

Seropositivity for HIV-1

Participant Groups

The study is testing the use of machine perfusion technology on discarded liver grafts. It involves taking biopsies before and after implantation to develop an index that can predict how well the liver will function post-transplant.

1Treatment groups

Experimental Treatment

Group I: BiopsyExperimental Treatment1 Intervention

Biopsies taken at protocol specified time points