MM120 for Generalized Anxiety Disorder

Recruiting in Palo Alto (17 mi)

+27 other locations

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: Mind Medicine, Inc.

Prior Safety Data

Trial Summary

What is the purpose of this trial?This trial is testing whether MM120 (LSD) can help people with generalized anxiety disorder. The study examines the effects of MM120 on generalized anxiety disorder. LSD affects the brain's serotonin system, potentially altering mood and anxiety. LSD was investigated for MDD, anxiety, and severe somatic disorders.

Eligibility Criteria

This trial is for adults with Generalized Anxiety Disorder who are in good health and have a BMI between 18 and 38 mg/kg2. It excludes those with certain psychiatric disorders or family history of them, pregnant or breastfeeding women, men unwilling to use contraception, anyone at significant suicide risk or taking prohibited medications.

Inclusion Criteria

Are you willing to avoid cannabis use during this 4 month study?

Do you have a friend or family member who will be able to meet you at the study clinic and drive you home after your single dosing day?

Exclusion Criteria

Have you ever been diagnosed with PTSD?

Have you or an immediate family member (child, sibling, parent) ever been diagnosed with Schizophrenia or Bipolar Disorder?

Have you used psychedelics in the past 2 years? e.g. LSD, MDMA, DMT, psilocybin, ayahuasca, mescaline, mushrooms, ecstasy

+1 more

Participant Groups

MM120 is a study drug that acts on serotonin in your brain. Researchers believe that MM120 could have possible benefits that may improve your general anxiety symptoms.

5Treatment groups

Experimental Treatment

Placebo Group

Group I: Arm 5- 200 μg MM-120 (LSD D-Tartrate)Experimental Treatment1 Intervention

A psychoactive substance that mediates effects mainly through an agonist activity in the serotonin 2A receptor (5-HT2A).

Group II: Arm 4- 100 μg MM-120 (LSD D-Tartrate)Experimental Treatment1 Intervention

A psychoactive substance that mediates effects mainly through an agonist activity in the serotonin 2A receptor (5-HT2A).

Group III: Arm 3- 50 μg MM-120 (LSD D-Tartrate)Experimental Treatment1 Intervention

A psychoactive substance that mediates effects mainly through an agonist activity in the serotonin 2A receptor (5-HT2A).

Group IV: Arm 2- 25 μg MM-120 (LSD D-Tartrate)Experimental Treatment1 Intervention

A psychoactive substance that mediates effects mainly through an agonist activity in the serotonin 2A receptor (5-HT2A).

Group V: Arm 1- PlaceboPlacebo Group1 Intervention