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Peppermint Essential Oil for Vomiting (CINV Trial)

N/A
Waitlist Available
Research Sponsored by Milton S. Hershey Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 72 hours post-chemotherapy
Awards & highlights

CINV Trial Summary

This trial is testing whether using a diffuser with ginger, peppermint, or vanilla extract can help reduce chemotherapy side effects.

Eligible Conditions
  • Vomiting
  • Nausea

CINV Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~72 hours post-chemotherapy
This trial's timeline: 3 weeks for screening, Varies for treatment, and 72 hours post-chemotherapy for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Acute Nausea Score
Delayed Nausea Score
Secondary outcome measures
Appetite During the 72 Hours Post-chemotherapy
Appetite For the 24 Hours Post-chemotherapy
Use of additional anti-emetic medications (in addition to the standard regimen's listed anti-emetics)

CINV Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: Peppermint Essential OilActive Control1 Intervention
Usual care plus a personal pocket diffuser prepared with 14 drops of peppermint essential oil. Each subject will be instructed to inhale from the pocket diffuser beginning on the day of their chemotherapy (Day 1) and continue using the inhaler for the next three consecutive days (Day 1-Day 4).The subjects will remove the cover of the pocket diffuser, place the pocket diffuser approximately an inch away from their nose and inhale three times with deep breathing (i.e., three sniffs). Subjects will take 3 sniffs of the aromatherapy inhaler three times daily (morning, afternoon, and evening).The subjects will complete a Pre-treatment Assessment form before cycle of chemotherapy (total of 2), as well as 24 and 72 hours after each cycle of chemotherapy. The exact same procedures will be repeated during the participant's next cycle of chemotherapy, which is likely two or three weeks after the first one.
Group II: Ginger Essential OilActive Control1 Intervention
Usual care plus a personal pocket diffuser prepared with 14 drops of ginger essential oil. Each subject will be instructed to inhale from the pocket diffuser beginning on the day of their chemotherapy (Day 1) and continue using the inhaler for the next three consecutive days (Day 1-Day 4). The subjects will remove the cover of the pocket diffuser, place the pocket diffuser approximately an inch away from their nose and inhale three times with deep breathing (i.e., three sniffs). Subjects will take 3 sniffs of the aromatherapy inhaler three times daily (morning, afternoon, and evening). The subjects will complete a Pre-treatment Assessment form before cycle of chemotherapy (total of 2), as well as 24 and 72 hours after each cycle of chemotherapy.The exact same procedures will be repeated during the participant's next cycle of chemotherapy, which is likely two or three weeks after the first one.
Group III: Pure Vanilla Extract (placebo-control)Placebo Group1 Intervention
Usual care plus a personal pocket diffuser prepared with 14 drops of pure vanilla extract (placebo). Each subject will be instructed to inhale from the pocket diffuser beginning on the day of their chemotherapy (Day 1) and continue using the inhaler for the next three consecutive days (Day 1-Day 4). The subjects will remove the cover of the pocket diffuser, place the pocket diffuser approximately an inch away from their nose and inhale three times with deep breathing (i.e., three sniffs). Subjects will take 3 sniffs of the aromatherapy inhaler three times daily (morning, afternoon, and evening). The subjects will complete a Pre-treatment Assessment form before cycle of chemotherapy (total of 2), as well as 24 and 72 hours after each cycle of chemotherapy. The exact same procedures will be repeated during the participant's next cycle of chemotherapy, which is likely two or three weeks after the first one.

Find a Location

Who is running the clinical trial?

Milton S. Hershey Medical CenterLead Sponsor
497 Previous Clinical Trials
2,799,958 Total Patients Enrolled
3 Trials studying Vomiting
200 Patients Enrolled for Vomiting
Doctors Kienle Center for Humanistic Medicine/Penn State College of MedicineUNKNOWN

Media Library

Peppermint Essential Oil Clinical Trial Eligibility Overview. Trial Name: NCT04478630 — N/A
Vomiting Research Study Groups: Peppermint Essential Oil, Pure Vanilla Extract (placebo-control), Ginger Essential Oil
Vomiting Clinical Trial 2023: Peppermint Essential Oil Highlights & Side Effects. Trial Name: NCT04478630 — N/A
Peppermint Essential Oil 2023 Treatment Timeline for Medical Study. Trial Name: NCT04478630 — N/A
~3 spots leftby Jun 2025
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