Behavioural Intervention
Electrical Nerve Stimulation for Depression
This trial aims to test the effectiveness of a non-invasive treatment called Electrical Vestibular Nerve Stimulation (VeNS) for Major Depressive Disorder (MDD). Participants will be randomly assigned
Behavioural Intervention
BI 1569912 for Depression
This trial tests a new medicine, BI 1569912, for adults with depression who haven't improved with other treatments. Participants take the medicine daily while continuing their usual therapy. The study checks if the new medicine helps reduce depression symptoms.
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Trials for Depression Patients
Procedure
Individualized TMS for Depression
This trial tests aiTBS, a magnetic brain stimulation method, on patients with depression that hasn't responded to other treatments. The treatment uses magnetic pulses to reset brain activity and improve mood. Participants will receive aiTBS either guided by brain scans or by physical measurements of the head. Intermittent Theta Burst Stimulation (iTBS) is a newer form of repetitive Transcranial Magnetic Stimulation (rTMS) that has shown potential for faster and more intense effects in treating depression.
tDCS for Major Depressive Disorder
This trial tests tDCS, a non-invasive brain stimulation technique, on patients with severe depression who haven't responded to multiple treatments. The goal is to see if tDCS can help improve their mood by using a small electrical current to stimulate specific brain areas. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that has been investigated for its potential to treat depression, especially in patients who do not respond well to medication.
Procedure
Theta Burst Stimulation for Adolescent Depression
This trial aims to study the effectiveness of a new treatment called Theta burst stimulation (TBS) for major depression in adolescents. They want to compare how well a new accelerated, three times a day T
Trials for Persistent Depressive Disorder Patients
Antidepressant
Bupropion for Depression
This trial tests a new treatment for children with depression. The effectiveness is measured by changes in depression symptoms. Fluoxetine has been shown to be effective in treating major depressive disorder in children and adolescents.
Omega-3 Fatty Acids
Vitamin D + Omega-3 for Depression
This trial is studying whether taking vitamin D3 or omega-3 fatty acids supplements reduces the risk of developing cancer, heart disease, and stroke. This study will also examine whether either of these supplements reduces the risk of clinical depression or improves mood scores over time.
Selective Serotonin Reuptake Inhibitor
Fluoxetine for Anxiety and Depression
This trial uses fMRI to study brain regions engaged in processing motivationally salient stimuli in children, adolescents, and adults with mood and anxiety disorders, in order to better understand how these disorders develop and how they can be treated.
Serotonin-Norepinephrine Reuptake Inhibitor
Exercise + Duloxetine for Knee Osteoarthritis
This trial tests a treatment combining duloxetine and aerobic exercise for adults with knee osteoarthritis and depression. Duloxetine helps manage pain and mood, making it easier for patients to stick to their exercise routine. Duloxetine, an anti-depressant medication, has been recently approved for managing knee osteoarthritis and has shown effectiveness in reducing pain and improving function in patients with osteoarthritis.
Phase 3 Trials
Psychedelic Therapy
Psilocybin for Depression
This trial is testing psilocybin, a substance from mushrooms, to see if it can help adults with depression who may not respond well to current treatments. Psilocybin works by affecting brain chemicals related to mood. Psilocybin has shown promise as a treatment for major depressive disorder and was designated as a breakthrough therapy by the FDA in 2019.
Aticaprant + Antidepressant for Depression
This trial aims to see if aticaprant is effective in preventing the return of depression symptoms when added to antidepressant therapy in individuals with major depressive disorder who have already responded well to aticaprant treatment
Seltorexant for Depression
This trial is testing seltorexant to see if it can help people with depression and insomnia who haven't improved with their current antidepressants. Seltorexant aims to improve mood and sleep by acting on certain brain receptors.
NMDA Antagonist
Ketamine for Bipolar Depression and Suicidal Thoughts
This trial tests a treatment that starts with a ketamine injection to quickly reduce severe depression and suicidal thoughts, followed by maintenance pills. It targets patients with severe bipolar depression who need rapid symptom relief. Ketamine rapidly alters brain activity, and the pills help maintain these positive changes. Ketamine has shown effectiveness as a rapid-acting antidepressant with antisuicidal effects, but evidence for long-term maintenance therapy is limited.
Trials With No Placebo
Procedure
Individualized TMS for Depression
This trial tests aiTBS, a magnetic brain stimulation method, on patients with depression that hasn't responded to other treatments. The treatment uses magnetic pulses to reset brain activity and improve mood. Participants will receive aiTBS either guided by brain scans or by physical measurements of the head. Intermittent Theta Burst Stimulation (iTBS) is a newer form of repetitive Transcranial Magnetic Stimulation (rTMS) that has shown potential for faster and more intense effects in treating depression.
Behavioral Intervention
Social-Cognitive Skills Training for Schizophrenia
This trial will adapt an evidence-based social cognitive skills intervention for use with Veterans in a work setting, in order to help them better understand and manage social interactions.
Procedure
Theta Burst Stimulation for Adolescent Depression
This trial aims to study the effectiveness of a new treatment called Theta burst stimulation (TBS) for major depression in adolescents. They want to compare how well a new accelerated, three times a day T
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Frequently Asked Questions
Introduction to major depressive disorder
What are the top hospitals conducting major depressive disorder research?
When it comes to advancing our understanding and treatment options for major depressive disorder (MDD), several hospitals are leading the way in clinical trials. In Orlando, APG Research, LLC is making strides with five active MDD trials and a total of five trials dedicated to this condition. While relatively new in the field, having recorded their first trial in 2018, their commitment to research shows promise for future breakthroughs. The University of Connecticut Health Center in Farmington has also been actively involved in MDD research since its initial trial back in 2003. With four ongoing trials and a cumulative count of nine completed studies, this institution is contributing significantly to the fight against depression.
Moving on to Chicago, we find the Chicago Research Center playing an important role with four active MDD trials and eleven previously conducted studies since their first recorded trial in 2007. They continue working tirelessly towards improving treatments for individuals living with MDD. Another facility making notable contributions is Baber Research Group located in Naperville. Although they have only been conducting MDD trials since 2012, they already have an impressive track record of nine past studies alongside their current involvement with four ongoing investigations.
Lastly but no less significant is Lehigh Center for Clinical Research situated at Allentown; despite being geographically smaller they contribute immensely through twenty-four previous experiments while currently hosting fouroperationalresearches concerning Major Depressive Disorder; retroactively starting from as early as year2006
These hospitals serve as beacons of hope for those suffering from major depressive disorder by dedicating substantial resources towards finding innovative solutions and enhancing patient outcomes. Through collaborative efforts between medical professionals and participants willing to volunteer for these clinical trials, we can pave the way toward improved treatments and a brighter future for individuals battling MDD worldwide
Which are the best cities for major depressive disorder clinical trials?
When it comes to clinical trials for major depressive disorder, several cities have emerged as hubs of research and innovation. Miami, Florida leads the pack with 18 active trials exploring treatments like Aticaprant, Seltorexant, and REL-1017. New york, New York and Dallas, Texas trail closely behind with 15 ongoing studies investigating therapeutic options such as Aticaprant and Tianeptine Sodium in New York; Aticaprant, Seltorexant, and Strategy 1 in Dallas. Other notable cities include Orlando, Florida with 13 active trials focusing on medications like Seltorexant and TNX-601 ER; and Houston, Texas with 12 ongoing studies examining NRX-101 and Esketamine among others. These cities provide individuals suffering from major depressive disorder access to cutting-edge clinical trials that offer hope for new treatment approaches.
Which are the top treatments for major depressive disorder being explored in clinical trials?
Exciting breakthroughs in the treatment of major depressive disorder are emerging from ongoing clinical trials. Leading the charge is ketamine, with its remarkable track record of 54 all-time trials and active involvement in five current studies since its introduction in 2006. Aticaprant, a newcomer to the scene, shows promise with three active trials dedicated to major depressive disorder since it was first listed in 2022. Seltorexant and psilocybin each have three active trials under their belt as well, contributing to their growing popularity among researchers exploring new avenues for treating this debilitating condition. Lastly, Left Dorsolateral Prefrontal Cortex (L-DLPFC) is making waves with two ongoing trials that focus on unlocking its potential against major depressive disorder. With these innovative treatments paving the way forward, hope shines brighter than ever for those grappling with this challenging mental health issue.
What are the most recent clinical trials for major depressive disorder?
Recent clinical trials offer promising prospects for individuals grappling with major depressive disorder. One notable trial investigates the efficacy of esketamine, a derivative of ketamine, in treating this debilitating condition. Additionally, combining ketamine with perampanel shows potential as an innovative treatment approach for major depressive disorder. Another study explores the benefits of high CBD [25:1] medication in alleviating symptoms associated with this mental health condition. Furthermore, omega-3 supplementation is being examined as a possible adjunctive therapy to traditional treatments for major depressive disorder. Lastly, venlafaxine demonstrates promise in managing symptoms and improving overall quality of life for those affected by major depressive disorder. These clinical trials open doors to new therapeutic options that may bring relief and hope to individuals navigating this challenging illness.
What major depressive disorder clinical trials were recently completed?
Recent clinical trials have made significant strides in the field of major depressive disorder research. In June 2022, Alto Neuroscience successfully completed a trial for ALTO-100 PO Tablet, followed by two more trials for the same medication in December 2021. Neurocrine Biosciences also achieved an important milestone with their NBI-1065846 trial in November 2021. Other notable completed studies include Cerevel Therapeutics' CVL-354 trial in October 2021 and Praxis Precision Medicines' PRAX-114 study in June 2021. These advancements highlight the ongoing efforts to uncover innovative approaches for better managing major depressive disorder and improving patients' quality of life.