Vessel Interruption Order for Lung Cancer
(CTC-01 Trial)

Recruiting in Palo Alto (17 mi)

Overseen byMassimo Conti, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Laval University

No Placebo Group

Trial Summary

What is the purpose of this trial?

This study aims to define the impact of the sequence of vessel interruption on change in CTC and CTC clusters density in the tumor-draining pulmonary vein between the period before surgical manipulation and before tumor-draining vein interruption.

Research Team

Massimo Conti, MD

Principal Investigator

Centre de Recherche IUCPQ - Laval University

Eligibility Criteria

This trial is for adults with non-small cell lung cancer (NSCLC) who have a certain type of tumor visible on a CT scan and are in the early stages of the disease. They must be candidates for minimally invasive lung surgery but haven't had thoracic surgery on the same side before, nor can they have received recent cancer treatment or have another active cancer.

Inclusion Criteria

My cancer is in an early stage and has not spread to lymph nodes or other parts of the body.

My lung cancer was confirmed by a biopsy before surgery.

I had a minimally invasive lung surgery.

See 1 more

Exclusion Criteria

You have not had a diagnosis based on tissue samples taken before surgery.

My first lung surgery was done by opening the chest with rib spreading.

I have had chest surgery on the same side before.

See 9 more

Treatment Details

Interventions

Arteries interruption before vein interruption (Procedure)
Vein interruption before any other surgical manipulation (Procedure)

Trial OverviewThe study is testing whether interrupting blood flow through veins before other surgical steps, or arteries before veins, affects circulating tumor cells during lung cancer surgery. The goal is to see if changing this sequence impacts how many tumor cells spread from the lungs into the blood.

Participant Groups

2Treatment groups

Active Control

Group I: Arteries before veinActive Control1 Intervention

Lobar arteries (+/- bronchus and inter-lobar fissures) are interrupted before tumor-draining pulmonary vein.

Group II: Vein firstActive Control1 Intervention

Tumor-draining pulmonary vein is interrupted first and before any surgical manipulation.