Diet Impact on Kidney Stones in Obese Individuals

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byDean G Assimos, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Alabama at Birmingham

No Placebo Group

Trial Summary

What is the purpose of this trial?The primary goals of this study are to determine the contribution of dietary oxalate absorption, renal oxalate handling, and endogenous oxalate synthesis to urinary oxalate excretion in normal Body Mass Index (BMI) and obese calcium oxalate kidney stone formers.

Eligibility Criteria

This trial is for adults with normal (BMI ≥ 18.5 to < 25) or obese (BMI ≥ 30 to ≤ 45) who form calcium oxalate kidney stones, can consent, and follow a controlled diet without vigorous exercise. Excluded are those with diabetes, abnormal blood tests, certain kidney diseases, gastrointestinal disorders affecting oxalate transport, recent cancer treatment, pregnancy or breastfeeding women not using birth control.

Inclusion Criteria

No food allergies or intolerance to any of the food in study menus

Willingness to not undertake vigorous exercise during the controlled dietary study

I am willing to stop my kidney stone prevention meds for the study duration.

+9 more

Exclusion Criteria

I have been diagnosed with primary hyperparathyroidism.

I have high oxalate levels in my urine due to intestinal issues.

Your fasting blood test shows abnormal results for your body's chemical levels.

+28 more

Participant Groups

The study investigates how obesity affects the body's processing of oxalate in people prone to calcium oxalate kidney stones. Participants will follow a controlled diet and ingest Carbon-13 Oxalate and Sucralose to track their metabolism and urinary excretion patterns.

1Treatment groups

Experimental Treatment

Group I: Controlled Dietary StudyExperimental Treatment2 Interventions

Participants will consume the controlled diet for five days. After one day on the diet, subjects will provide three 24-hour urine collections. On the last dayof the diet, subjects will come in a fasted state to ingest a small amount of carbon-13 oxalate and sucralose, with hourly urine collections and blood samples being taken before and after the ingestion.