Cognitive Bias Modification for Obsessive-Compulsive Disorder
Recruiting in Palo Alto (17 mi)
Overseen ByHanjoo Lee, PhD
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Han Joo Lee
No Placebo Group
Approved in 1 jurisdiction
Trial Summary
What is the purpose of this trial?Thought-Action-Fusion (TAF) is a cognitive bias that posits (1) having unwanted thoughts is morally equivalent to acting upon the thoughts (TAF-Moral; e.g., "Thinking about harming a child is as immoral as actually harming a child") and (2) having unwanted thoughts will increase the likelihood of the thoughts happening in real life (TAF-Likelihood; e.g., "My mother will get into a car accident, because I thought about it"). Given its central role in the development and maintenance of OCD, TAF has emerged as a potential treatment target for obsessive-compulsive disorder (OCD). Previous research has demonstrated that TAF is indeed a malleable construct. This study aims to examine the effects of a multi-session, personalized cognitive bias modification (CBM) for thought-action-fusion (TAF) on improving obsessive-compulsive (OC) symptoms in a college sample.
What data supports the idea that Cognitive Bias Modification for Obsessive-Compulsive Disorder is an effective treatment?The available research shows that Cognitive Bias Modification (CBM) for Obsessive-Compulsive Disorder (OCD) can be effective. One study found that CBM helped change the way people interpret situations, which is important for reducing OCD symptoms. In a trial, people who received CBM showed a significant improvement in how they interpreted situations compared to those who only received educational information. Another study is testing an online version of CBM to see if it works as well as in-person treatments. Overall, these studies suggest that CBM can be a helpful treatment for OCD, but more research is needed to confirm its effectiveness.345910
Do I have to stop taking my current medications for this trial?The trial protocol does not specify whether you need to stop taking your current medications.
Is CBM-TAF a promising treatment for OCD?Yes, CBM-TAF is a promising treatment for OCD. It helps change negative thinking patterns and has shown positive effects in reducing symptoms of anxiety, depression, and addiction. Studies suggest it can improve how people interpret situations, making it a valuable addition to traditional OCD treatments.457810
What safety data is available for Cognitive Bias Modification in treating OCD?The provided research does not specifically address safety data for Cognitive Bias Modification (CBM) in treating OCD or related protocols like CBM-SMP, CBM-TAF, or Personalized CBM. The studies focus on the efficacy, therapeutic impact, and acceptability of CBM in various disorders, including anxiety and depression, but do not provide detailed safety evaluations.12346
Eligibility Criteria
This trial is for college individuals with Obsessive-Compulsive Disorder (OCD) who experience Thought-Action-Fusion, where they believe unwanted thoughts are morally wrong or likely to become real. Specific eligibility criteria details were not provided.Inclusion Criteria
I am 18 years old or older.
Participant Groups
The study tests a personalized cognitive bias modification program targeting Thought-Action-Fusion biases in OCD patients. It aims to see if changing these thought patterns can improve OCD symptoms over multiple sessions.
3Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Bias Modification for Thought-Action-Fusion (CBM-TAF)Experimental Treatment1 Intervention
CBM-TAF will employ an ambiguous sentence-completion task, where participants have to fill in a missing letter in a fragmented word and resolve emotional ambiguity of a given scenario. At the beginning of each training session, participants will watch a brief animated video about TAF, OCD, and modifying TAF. Each training session will consist of 40 scenarios, which will take about 20 minutes to complete. There will be a total of 6 sessions (2x/week for 3 weeks).
Group II: Cognitive Bias Modification for Stress Management Psychoeducation (CBM-SMP)Active Control1 Intervention
Similar to CBM-TAF, CBM-SMP will employ an ambiguous sentence-completion task, where participants have to fill in a missing letter in a fragmented word. However, the content of scenarios in CBM-SMP will focus on general stress management techniques. At the beginning of each training session, participants will watch a brief animated video about OCD and stress management techniques. Each training session will consist of 40 scenarios, which will take about 20 minutes to complete. There will be a total of 6 sessions (2x/week for 3 weeks).
Group III: Waitlist (WL)Active Control1 Intervention
Participants in WL group will only complete weekly assessment measures without engaging in any training sessions.
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
UWM Anxiety Disorders LaboratoryMilwaukee, WI
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Who is running the clinical trial?
Han Joo LeeLead Sponsor
Psi ChiCollaborator
Psi ChiCollaborator
References
Combined cognitive bias modification treatment for social anxiety disorder: a pilot trial. [2021]Cognitive Bias Modification (CBM) is a promising treatment for Social Anxiety Disorder (SAD). However, previous randomized trials have not systematically examined the combination of CBM for attention (CBM-A) and interpretation (CBM-I) or the credibility and acceptability of these protocols.
Socially anxious primary care patients' attitudes toward cognitive bias modification (CBM): a qualitative study. [2021]Cognitive bias modification (CBM) is a novel treatment for anxiety disorders that utilizes computerized tasks to train attention and interpretation biases away from threat. To date, attitudes toward and acceptability of CBM have not been systematically examined.
Cognitive bias modification procedures in the management of mental disorders. [2022]To review recent research on the therapeutic impact of cognitive bias modification (CBM) procedures, designed to train direct change in the patterns of attentional and interpretive bias known to characterize particular forms of psychopathology.
Cognitive Bias Modification (CBM) of obsessive compulsive beliefs. [2021]Cognitive bias modification (CBM) protocols have been developed to help establish the causal role of biased cognitive processing in maintaining psychopathology and have demonstrated therapeutic benefits in a range of disorders. The current study evaluated a cognitive bias modification training paradigm designed to target interpretation biases (CBM-I) associated with obsessive compulsive disorder (OCD).
Internet-based cognitive bias modification for obsessive compulsive disorder: study protocol for a randomized controlled trial. [2021]Cognitive bias modification (CBM) interventions have demonstrated efficacy in augmenting core biases implicated in psychopathology. The current randomized controlled trial (RCT) will evaluate the efficacy of an internet-delivered positive imagery cognitive bias modification intervention for obsessive compulsive disorder (OCD) when compared to a control condition.
Efficacy of cognitive bias modification interventions in anxiety and depression: meta-analysis. [2022]Cognitive bias modification (CBM) interventions are strongly advocated in research and clinical practice.
Imagery versus verbal interpretive cognitive bias modification for compulsive checking. [2019]Pathological doubting and checking is a common symptom presentation in obsessive-compulsive disorder (OCD). Previous research has established that compulsive checkers do not display an actual memory deficit, but lack confidence in their memories and experience intolerance of uncertainty regarding the completion of tasks. We investigated whether interpretive cognitive bias modification (CBM-I) reduced memory distrust and intolerance of uncertainty in a nonclinical sample. We also examined the possible enhancement of CBM-I for OCD through imagery training. The results provide evidence that participants who received positive imagery CBM-I training may have interpreted novel ambiguous checking scenarios more adaptively and endorsed negative checking beliefs less relative to participants in the control imagery CBM-I condition. Findings on behavioural checking tasks did not indicate any specific response to CBM-I training. Future research may translate these suggestive findings into a useful adjunct to traditional strategies targeting maladaptive OCD beliefs.
Imaging the neural effects of cognitive bias modification training. [2018]Cognitive bias modification (CBM) was first developed as an experimental tool to examine the causal role of cognitive biases, and later developed into complementary interventions in experimental psychopathology research. CBM involves the "re-training" of implicit biases by means of multiple trials of computerized tasks, and has been demonstrated to change anxious, depressive and drug-seeking behavior, including clinically relevant effects. Recently, the field has progressed by combining CBM with neuroimaging techniques, which provides insight into neural mechanisms underlying how CBM affects implicit biases in anxiety, depression, and addiction, and potentially other pathologies. This narrative literature review summarizes the state of the art of studies on the neural effects of CBM and provides directions for future research in the field. A total of 13 published studies were found and discussed: n=9 in anxiety, n=2 in depressive behavior, and n=2 in addiction.
From cognitive targets to symptom reduction: overview of attention and interpretation bias modification research. [2023]Cognitive bias modification (CBM) is a class of mechanised psychological interventions designed to target specific aberrant cognitive processes considered key in the aetiology and/or maintenance of specific psychiatric disorders. In this review, we outline a multistage translational process that allows tracking progress in CBM research. This process involves four steps: (1) the identification of reliable cognitive targets and establishing their association with specific disorders; (2) clinical translations designed to rectify the identified cognitive targets; (3) verification of effective target engagement and (4) testing of clinical utility in randomised controlled trials. Through the prism of this multistage process, we review progress in clinical CBM research in two cognitive domains: attention and interpretation; in six psychiatric conditions: anxiety disorders, major depressive disorder, post-traumatic stress disorder, addictive disorders, eating disorders and obsessive-compulsive disorder. The review highlights achievement as well as shortcomings of the CBM approach en route to becoming a recognised evidence-supported therapy for these disorders.
Feasibility and Acceptability of Cognitive Bias Modification for Interpretation as an Adjunctive Treatment for OCD and Related Disorders: A Pilot Randomized Controlled Trial. [2022]Cognitive models implicate interpretation bias in the development and maintenance of obsessive compulsive and related disorders (OCRDs), and research supports Cognitive Bias Modification for Interpretation (CBM-I) in targeting this mechanism. However, prior studies in OCRDs have been limited to nonclinical populations, adolescents, and adults in a laboratory setting. This study evaluated the feasibility and acceptability of CBM-I as an adjunctive intervention during intensive/residential treatment (IRT) for adults with OCRDs. We modified a lab-based CBM-I training for adults seeking IRT for OCRDs, and conducted a feasibility trial (N = 4) and subsequent pilot RCT; participants (N = 31) were randomized to receive CBM-I or psychoeducation. Benchmarks were met for feasibility, acceptability, and target engagement. From pre- to post-intervention, the CBM-I group showed a large effect for change in interpretation bias (d = .90), whereas this effect was trivial (d = .06) for psychoeducation. This was the first study to evaluate CBM-I in naturalistic treatment for adults seeking IRT for OCRDs. Findings support the feasibility and acceptability of CBM-I in this novel sample and setting. A larger scale RCT is needed to determine whether CBM-I can enhance OCRD treatment response.