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Pain Informed Movement for Knee Osteoarthritis

N/A

Recruiting

Led By Lisa Carlesso, PhD

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year

Awards & highlights

No Placebo-Only Group

Summary

This trial will compare two interventions for knee osteoarthritis to see if there are differences in pain, functional leg strength, pain modulation, and psychological factors.

Who is the study for?

This trial is for people over 40 with knee osteoarthritis who've had regular pain in the past month. They must speak English, have internet access, and be able to move without help. It's not for those with recent knee trauma/surgery, injections in the knee within 3 months, or involved in other OA trials.

What is being tested?

The study compares a pain informed movement program plus Pain Neuroscience Education (PNE) against standard neuromuscular exercises with basic OA education. It checks which is more feasible and satisfactory for patients and measures effects on pain, function, quality of life, strength, nerve factors.

What are the potential side effects?

While specific side effects are not listed here as it's an exercise-based intervention rather than drug-related; general risks may include muscle soreness or strain from physical activities.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Percentage of follow up

Secondary study objectives

Frequency of the program measured on a 5 point Likert scale

Rate of recruitment measured by number of people recruited in a year

Usefulness of the education content measured on a 5 point Likert scale

+5 more

Other study objectives

30 Second Sit to Stand Test

Brief Fear of Movement Scale for Osteoarthritis (BFMSO)

Conditioned Pain modulation (CPM) measured with PPT test stimulus and conditioning stimulus of forearm ischemia

+16 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Pain Informed Movement and pain neuroscience educationExperimental Treatment2 Interventions

Participants will receive a twice weekly, 8 week in-person group exercise program, consisting of exercise instruction (75 minutes) and pain neuroscience education (PNE) videos (20 to 30 minutes/week for the first 4 weeks). During the exercise sessions, the educational components and concepts such as mindfulness, muscle tension regulation, and breathing techniques will be applied by the instructor. A third home session (weekly) will be facilitated by exercise handout sheets. The exercise component will be delivered by an experienced yoga teacher that has been extensively trained. The PNE video component will cover the following topics: The purpose of pain, neurophysiological changes of pain, movement guidelines when pain persists, and self-care techniques to impact neurophysiology and support moving with ease that include breath awareness and regulation, muscle tension regulation, awareness of pain related thoughts and emotions, relaxation, and body awareness.

Group II: Standard neuromuscular exercise and OA educationActive Control2 Interventions

Participants in this group will receive an 8-week in-person group exercise program held twice weekly, in which they will receive exercise instructions (60 minutes) and standard osteoarthritis (OA) education (15 to 20 minutes/week for the first 4 weeks). A third home session (weekly) will be facilitated by exercise handout sheets. The exercise component (i.e., the specific movements) of this group will be similar to those of the other group without the added techniques of breath awareness and regulation, muscle tension regulation, awareness of pain related thoughts and emotions, relaxation, and body awareness. The standard OA education videos will cover the following topics: common OA symptoms, risk factors associated with knee OA, and the effects of exercise and self-management tips. The exercise and education components will be delivered by a physiotherapist in the research team.

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