Eating Beans for Obesity
Recruiting in Palo Alto (17 mi)
Overseen byShanon Casperson, PhD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: USDA Grand Forks Human Nutrition Research Center
Must not be taking: Steroids, Antidepressants
Disqualifiers: Pregnancy, Lactation, Hypertension, Cardiovascular, others
No Placebo Group
Trial Summary
What is the purpose of this trial?The purpose of this research is to test how eating a meal containing beans impacts how participants' bodies use food for energy.
Will I have to stop taking my current medications?
If you are taking medications that affect appetite, blood lipids (fats in the blood), body composition, body weight, or food intake, you will need to stop taking them to participate in this trial. The trial does not specify a washout period (time without taking certain medications), but these medications are not allowed.
What data supports the effectiveness of the treatment involving pinto beans for obesity?
Research suggests that extracts from Phaseolus vulgaris (the scientific name for pinto beans) can help with weight control by reducing fat accumulation and blocking carbohydrate absorption, which may lead to weight loss.
12345Is eating beans safe for humans?
Beans, including pinto beans and other types of Phaseolus vulgaris, are widely consumed and generally considered safe for human consumption. Some studies suggest they may have health benefits, such as reducing cancer risk and aiding in weight management, without significant safety concerns.
12367How does eating pinto beans help with obesity compared to other treatments?
Eating pinto beans, like other beans, may help with obesity by increasing satiety (feeling full) and reducing body fat and waist size. Beans are unique because they can improve lipid metabolism (how the body processes fats) and may block carbohydrate absorption, which can aid in weight control.
458910Eligibility Criteria
This trial is for adults with a BMI between 18.5 and 30 who can sign consent, are on birth control if applicable, have their own transport to the research center, don't smoke or use tobacco products including e-cigarettes, aren't taking steroids or trying to change their weight.Inclusion Criteria
You do not smoke or use any other tobacco products, including e-cigarettes.
I can travel to the Grand Forks Human Nutrition Research Center.
Your body mass index (BMI) is between 18.5 and 30 kg/m2.
+3 more
Exclusion Criteria
Participation in a weight loss diet/exercise program
Non-English speaking
I cannot or will not eat the food provided in the study.
+7 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
1-2 weeks
Treatment
Participants consume meals containing either whole cooked pinto beans, pinto bean flour, or a control meal to assess substrate oxidation
1 day
1 visit (in-person)
Follow-up
Participants are monitored for substrate utilization and energy expenditure after meal consumption
5 hours
1 visit (in-person)
Participant Groups
The study examines how eating meals containing whole cooked pinto beans or pinto bean flour compares to a control meal without beans in terms of affecting metabolism and energy use in the body.
3Treatment groups
Experimental Treatment
Active Control
Group I: Whole cooked pinto bean mealExperimental Treatment1 Intervention
Participants will consume a meal comprised of 100 grams of whole cooked pinto beans
Group II: Pinto bean flour mealExperimental Treatment1 Intervention
Participants will consume a meal comprised of pinto bean flour equivalent to 100 grams of whole cooked pinto beans
Group III: Control mealActive Control1 Intervention
Participants will consume a control meal
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
USDA Grand Forks Human Nutrition Research CenterGrand Forks, ND
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Who Is Running the Clinical Trial?
USDA Grand Forks Human Nutrition Research CenterLead Sponsor
References
Beanblock® (standardized dry extract of Phaseolus vulgaris) in mildly overweight subjects: a pilot study. [2018]This study evaluates the efficacy of Beanblock®, a standardized extract of Phaseolus vulgaris L., on weight control in healthy overweight subjects on a weight management plan that combined lifestyle and dietary advice.
Effects of Phaseolus vulgaris Extract on Lipolytic Activity and Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes: A Strategy to Prevent Obesity. [2022]Label="BACKGROUND" NlmCategory="BACKGROUND">Overweight and obesity are defined as abnormal or excessive fat accumulation that may be harmful for health. A global trend in this area is the search for natural compounds that have a proven beneficial effect and no clinical complications. Phaseolus vulgaris (bean) is a vegetable highly consumed worldwide. One of its effects, the most reported, is weight reduction in overweight individuals.
Cell signaling pathways associated with a reduction in mammary cancer burden by dietary common bean (Phaseolus vulgaris L.). [2021]Emerging evidence indicates that common bean (Phaseolus vulgaris L.) is associated with reduced cancer risk in human populations and rodent carcinogenesis models. This study sought to identify cancer-associated molecular targets that mediate the effects of bean on cancer burden in a chemically induced rat model for breast cancer. Initial experiments were conducted using a high dietary concentration of bean (60% wt/wt) where carcinoma burden in bean-fed rats was reduced 62.2% (P
Blocking carbohydrate absorption and weight loss: a clinical trial using a proprietary fractionated white bean extract. [2016]A proprietary fractionated white bean extract of Phaseolus vulgaris has been shown in vitro to inhibit the digestive enzyme alpha-amylase. This may prevent or delay the digestion of complex carbohydrates, potentially resulting in weight loss.
Food intake and satiety following a serving of pulses in young men: effect of processing, recipe, and pulse variety. [2019]Diets containing beans have been associated with a lower risk of obesity and overweight in several dietary surveys. These results suggest a benefit might be derived from beans and other pulses, possibly due to improved satiety or satiation and therefore lowering energy intake. Such a hypothesis has not been tested.
Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice. [2021]Based on the protective effects of cooked dry bean consumption in a human intervention study, we evaluated which fraction of cooked dry beans is responsible for its cancer-preventive effects. Cooked navy beans (whole beans), the insoluble fraction (bean residue) or soluble fraction of the 60% (vol:vol) ethanol extract of cooked navy beans (bean extract), or a modified AIN-93G diet (16.6% fat including 12.9% lard) as control diet were fed to 160 male obese ob/ob mice after 2 azoxymethane injections. In comparison to control-fed mice, dysplasia, adenomas, or adenocarcinomas were detected in fewer mice on either bean fraction diet (percent reduction from control: whole beans 54%, P=0.10; bean residue 81%, P=0.003; bean extract 91%, P=0.007), and any type of colon lesions, including focal hyperplasia, were found in fewer mice on each of the 3 bean diets percent reduction from control: whole bean 56%, P=0.04; bean residue 67%, P=0.01; bean extract 87%, P=0.0003. These results suggest that both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans.
Antinutritional factors in anasazi and other pinto beans (Phaseolus vulgaris L.). [2019]Antinutritional factors of anasazi bean were compared to traditional pinto bean (Phaseolus vulgaris L.). Anasazi beans contained less (p0.05) in stachyose and raffinose content were found between the two bean types; verbascose was not detected at all. Significant (p0.05) in inhibitor activity against human and bovine trypsin and chymotrypsin were found between the two bean types.
Canned Navy Bean Consumption Reduces Metabolic Risk Factors Associated with Obesity. [2017]The high prevalence of obesity and its metabolic co-morbidities require dietitians to promote lifestyle modifications that can be effectively implemented into practice and are feasible for customers to adhere to. The objective of this study was to determine the effect of commercially available ready-to-eat canned navy beans added to the habitual diet on risk factors associated with obesity. Fourteen overweight and obese adults consumed 5 cups of canned navy beans per week for 4 weeks. The study results demonstrated that bean consumption results in reduced waist circumference in females by 2.5 cm and males by 2.1 cm (P
Beneficial Effects of Common Bean on Adiposity and Lipid Metabolism. [2018]In developed countries which are at the epicenter of the obesity pandemic, pulse crop consumption is well below recommended levels. In a recent systematic review and meta-analysis of 21 randomized controlled clinical trials, pulse consumption was associated with improved weight control and reduced adiposity, although the underlying mechanisms were a matter of speculation. Common bean (Phaseolus vulgaris L.) is the most widely consumed pulse crop and was the focus of this investigation. Using outbred genetic models of dietary induced obesity resistance and of dietary induced obesity sensitivity in the rat, the impact of bean consumption was investigated on the efficiency with which consumed food was converted to body mass (food efficiency ratio), body fat accumulation, adipocyte morphometrics, and patterns of protein expression associated with lipid metabolism. Cooked whole bean as well as a commercially prepared cooked bean powders were evaluated. While bean consumption did not affect food efficiency ratio, bean reduced visceral adiposity and adipocyte size in both obesity sensitive and resistant rats. In liver, bean consumption increased carnitine palmitoyl transferase 1, which is the rate limiting step in long chain fatty acid oxidation and also resulted in lower levels of circulating triglycerides. Collectively, our results are consistent with the clinical finding that pulse consumption is anti-obesogenic and indicate that one mechanism by which cooked bean exerts its bioactivity is oxidation of long chain fatty acids.
Bean Consumption Accounts for Differences in Body Fat and Waist Circumference: A Cross-Sectional Study of 246 Women. [2020]Beans and other legumes have multiple nutritional qualities that reduce the risk of many diseases. However, the link between legume intake and obesity remains unclear. Therefore, the present study was designed to examine the association between bean intake, body fat percentage (BF%), and waist circumference, in 246 women. BF% was measured using dual-energy X-ray absorptiometry (DXA). Bean intake was assessed using the Block Food Frequency Questionnaire and indexed using total cups of bean-based food items and also factor scores derived from a factor analysis showing adherence to a bean-based dietary pattern. Bean consumption was expressed as cups per 1000 kilocalories. Regression results showed that the relationship between bean intake (total cups) and BF% was inverse and linear (F = 7.4, P=0.0069). Moreover, with bean consumption being divided into tertiles, there were mean differences across groups in BF% (F = 7.4, P=0.0008) and waist circumference (F = 4.2, P=0.0164). Specifically, women who consumed moderate or high amounts of beans had less body fat and smaller waists than those with low intakes. Similarly, using tertiles to categorize participants based on adherence to a bean-based dietary pattern, developed using factor analysis, those with low adherence had higher BF% (F = 7.9, P=0.0005) and larger waists (F = 4.5, P=0.0118) than their counterparts. The associations remained significant after adjusting for potential confounders. In conclusion, beans and other legumes seem to have dietary qualities that may be beneficial in the battle against obesity.