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B3: Blockade of three nerves for Postoperative Pain (THAMBUS Trial)

N/A
Waitlist Available
Led By Birgitte M Krogh, MD
Research Sponsored by Bispebjerg Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one week
Awards & highlights
Approved for 10 Other Conditions
All Individual Drugs Already Approved

Summary

Patients undergoing total hip arthroplasty may experience severe postoperative pain. This is normally treated with opioids, which can cause side effects such as nausea, vomiting, obstipation and sedation. The hypothesis is that patients receiving peripheral nerve blockade of three nerves leading pain stimuli from the hip will experience less pain, will consume less opioid and therefore have less side effects, and will be mobilized more quickly than patients not receiving the peripheral nerve blockade.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at intervals during the first 48 hours after surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and at intervals during the first 48 hours after surgery for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Bowel movement
Length of stay
Mental and physical condition
+5 more

Awards & Highlights

Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: B3: Blockade of three nervesActive Control5 Interventions
Peripheral nerve blockade of the femoral nerve, the anterior division of the obturator nerve, and the lateral femoral cutaneous nerve with ropivacaine.
Group II: B2: Blockade of 2 nervesActive Control6 Interventions
Peripheral nerve blockade of the anterior division of the obturator nerve and the lateral femoral cutaneous nerve with ropivacaine. Sham blockade of the femoral nerve with saline.
Group III: K: Control groupPlacebo Group5 Interventions
Sham blockade of the femoral nerve, the anterior division of the obturator nerve, and the lateral femoral cutaneous nerve with saline.

Find a Location

Who is running the clinical trial?

Bispebjerg HospitalLead Sponsor
402 Previous Clinical Trials
5,339,770 Total Patients Enrolled
2 Trials studying Postoperative Pain
140 Patients Enrolled for Postoperative Pain
Birgitte M Krogh, MDPrincipal InvestigatorBispebjerg Hospital
Kenneth Jensen, MDStudy DirectorBispebjerg Hospital
3 Previous Clinical Trials
220 Total Patients Enrolled
~6 spots leftby Oct 2025
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