Cortical Stimulation for Parkinson's Disease
(PC+S_PFC Trial)

Recruiting in Palo Alto (17 mi)

Overseen bySimon J Little, MBBS, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Philip Starr

No Placebo Group

Trial Summary

What is the purpose of this trial?This study will investigate cortical stimulation to treat mood and behavioral symptoms in Parkinson's disease patients.

Eligibility Criteria

This trial is for Parkinson's disease patients aged 30-75 with severe movement symptoms despite medication, who may benefit from deep brain stimulators. They should have mood or behavioral issues like depression or anxiety and show improvement on medication. Excluded are pregnant women, those with significant cognitive impairment, prior intracranial surgery (other than DBS), major comorbidities, or conditions that could interfere with the study.

Inclusion Criteria

My Parkinson's symptoms improve by at least 30% when I take my medication.

I have Parkinson's with severe tremor not improved by medication or I can't tolerate the medication.

Have one or several mild to moderate mood or impulsive behavior as defined by: depression (BDI>=13), anxiety (BAI >=7), impulsive behavior as indicated by a positive score on the QUIP-A (Questionnaire for Impulsive-Compulsive disorders in Parkinson's Disease) or as determined by clinical interview or informant report

+6 more

Exclusion Criteria

Any personality or mood symptoms that study personnel believe will interfere with study requirements.

I have had brain surgery, but not for deep brain stimulation.

My immune system is weak.

+9 more

Participant Groups

The study tests cortical stimulation using Activa PC+S Prefrontal to alleviate mood and behavioral symptoms in Parkinson's patients. Participants will be selected based on specific criteria including their response to medications and severity of symptoms.

1Treatment groups

Experimental Treatment

Group I: PD with mood disorder or impulsivityExperimental Treatment1 Intervention

This is a single-center study of the neurophysiology of non-motor symptoms such as anxiety, depression, and impulsivity that are comorbid in Parkinson's Disease.