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Contrast Agent

MRI with parotid gland stimulation for Parotid Tumors (SPIT Trial)

N/A
Waitlist Available
Led By Jonn Wu
Research Sponsored by British Columbia Cancer Agency
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age ≥ 18 Healthy normal volunteer
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up time to recruit 10 healthy volunteers (approximately 4 months)
Awards & highlights

Summary

The aim of this study is to determine the feasibility of demonstrating the following physiologically-descriptive quantities ('metrics'): the volume of plasma/volume of tissue (νp), Apparent Diffusion Coefficient (ADC), the volume of extracellular extravascular space per volume of tissue (νe), and the contrast agent transfer coefficients (Ktrans) pre and post parotid stimulation in 10 healthy volunteers. Feasibility will be defined as 80% of volunteers achieving detectable signal changes in pre/post salivary MR images.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~time to recruit 10 healthy volunteers (approximately 4 months)
This trial's timeline: 3 weeks for screening, Varies for treatment, and time to recruit 10 healthy volunteers (approximately 4 months) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility study of MRI imaging on parotid gland stimulation.

Trial Design

1Treatment groups
Experimental Treatment
Group I: MRI with parotid gland stimulationExperimental Treatment3 Interventions
All participants will have MRI imaging of the parotid gland with IV Gadovist pre and post parotid stimulation with lemon juice. 0.05 ml/kg of Gadovist (at 4 ml/s) and 20 ml of saline flush (also at 4 ml/s) will be administered. Approximately three minutes after scan commencement, the salivary glands will be stimulated by orally administering a small portion (≈5 ml) of Citric acid.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MRI
2009
Completed Phase 2
~1620

Find a Location

Who is running the clinical trial?

British Columbia Cancer AgencyLead Sponsor
172 Previous Clinical Trials
90,594 Total Patients Enrolled
Jonn WuPrincipal InvestigatorBritish Columbia Cancer Agency
~1 spots leftby Sep 2025
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