Cognitive Processing Therapy vs. Relaxation Training for PTSD

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Rush University Medical Center

No Placebo Group

Trial Summary

What is the purpose of this trial?The overall goal of this randomized controlled trial with partial crossover is to compare the effectiveness of 1-week virtual massed Cognitive Processing Therapy (CPT) to 5-day virtual relaxation training (RT) with regard to their ability to reduce posttraumatic stress disorder (PTSD) symptoms. Specifically, this study is designed to 1) examine changes in PTSD symptoms during and following the respective intervention, and 2) explore possible psychological treatment mechanisms, including cognitive control, inhibition, self-efficacy, and memory, and 3) examine possible moderators of treatment success (e.g. neuropsychological factors).

Eligibility Criteria

This trial is for English-speaking adults with PTSD who are interested in intensive therapy. Participants must have experienced a traumatic event, be stable on any psychotropic meds for at least a month, and commit to daily sessions over one week. Exclusions include recent trauma, unstable medical conditions, current legal actions related to the trauma, unmanaged psychosis or mania, recent substance abuse treatment needs, and sensory impairments.

Inclusion Criteria

I have been diagnosed with PTSD by a professional using a specific scale.

Are fluent in English

Have experienced a Criterion A traumatic event during their lifetime

+3 more

Exclusion Criteria

I haven't been on a steady dose of mental health medication for a month.

I experienced a traumatic event within the last month.

They are currently suicidal or homicidal (i.e., plan and intent)

+8 more

Participant Groups

The study compares two virtual treatments: massed Cognitive Processing Therapy (CPT) delivered over one week versus Relaxation Training (RT) given the same way. It aims to assess changes in PTSD symptoms and understand psychological mechanisms that may influence treatment success.

2Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive Processing Therapy (CPT)Experimental Treatment1 Intervention

Group II: Relaxation Training (RT)Active Control1 Intervention

Cognitive Processing Therapy is already approved in United States, European Union for the following indications:

🇺🇸 Approved in United States as Cognitive Processing Therapy for: