Physical Activity for Lymphoblastic Leukemia
Recruiting in Palo Alto (17 mi)
Age: < 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Connecticut Children's Medical Center
Must be taking: Chemotherapy
Disqualifiers: Non-ALL, Non-English, Age, others
No Placebo Group
Approved in 1 Jurisdiction
Trial Summary
What is the purpose of this trial?The purpose of the study is to evaluate the impact of exercise on physical activity levels and quality of life in children with acute lymphoblastic leukemia (ALL) receiving maintenance chemotherapy.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It seems likely that you can continue your current chemotherapy treatment, as the study involves children with leukemia who are already receiving maintenance chemotherapy.
What data supports the effectiveness of the treatment Physical Activity for Lymphoblastic Leukemia?
Research shows that exercise can improve physical performance and body composition in patients with acute lymphoblastic leukemia (ALL), similar to healthy individuals. Encouraging physical activity in ALL survivors is important as it correlates with better muscle performance and helps avoid obesity.
12345Is physical activity safe for people with acute lymphoblastic leukemia?
Research suggests that exercise is generally safe for children with acute lymphoblastic leukemia (ALL) during and after treatment, although they may experience lower levels of physical activity compared to healthy children. Exercise programs can help prevent some side effects of ALL treatment, like reduced bone density and impaired motor skills.
24567How does the physical activity treatment for lymphoblastic leukemia differ from other treatments?
This treatment is unique because it focuses on incorporating physical activity, such as exercise routines, to improve physical performance and body composition in patients with acute lymphoblastic leukemia (ALL). Unlike traditional treatments that primarily involve chemotherapy, this approach aims to counteract the negative effects of cancer therapy on physical fitness and quality of life.
12345Eligibility Criteria
This trial is for children aged 8-18 with acute lymphoblastic leukemia (ALL) who are in the maintenance phase of chemotherapy, can speak and read English, have no exercise contraindications as per their oncologist, live with parents/guardians who consent to participation, and don't have psychiatric or neurological disorders affecting study involvement.Inclusion Criteria
I do not have any mental or neurological conditions that would prevent me from participating.
Capable of speaking and reading English
Currently living with their parents/legal guardians
+4 more
Exclusion Criteria
I am not on chemotherapy during this study.
I am either younger than 8 or older than 18 years old.
I am an English speaker.
+1 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants engage in physical activities such as Nintendo WII fit, Xbox Kinect fit, and other sports activities during maintenance chemotherapy
1 year
Follow-up
Participants are monitored for quality of life, physical activity, sleep, and fatigue levels after treatment
4 weeks
Participant Groups
The study aims to assess how moderate physical activity affects the quality of life and activity levels in pediatric patients undergoing maintenance chemotherapy for ALL. It will measure changes due to exercise during this treatment phase.
1Treatment groups
Experimental Treatment
Group I: Physical ActivityExperimental Treatment1 Intervention
Single arm study where patients choose from physical activities after baseline assessment by PT. Activities include the following: Nintendo WII fit console, Xbox Kinect fit console and other sport activities.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Connecticut Children's Medical CenterHartford, CT
Loading ...
Who Is Running the Clinical Trial?
Connecticut Children's Medical CenterLead Sponsor
References
Physical performance of nontransplanted childhood ALL survivors is comparable to healthy controls. [2013]Physical fitness is an essential feature of overall health. Our objective was to compare the physical performance between nontransplanted acute lymphoblastic leukemia (ALL) patients (study patients), healthy controls, and ALL patients after stem cell transplantation (SCT). Forty-five ALL patients (median age, 13.3 y) treated without cranial irradiation were compared with 34 ALL patients (12.0 y) treated with SCT and total body irradiation and 522 age-matched and sex-matched controls. Their physical performance was assessed by 6 muscle tests measuring speed and dynamic endurance, flexibility, acceleration, maximal speed, and speed differentiation. The patients were tested at a minimum of 3 years after treatment. The muscle test results of the study patients did not differ from that of the healthy controls. The study patients had normal body mass indexes (BMI). Only 42% of them exercised at least once a week. Those who exercised >3 times a week and those with a BMI below median had better results. SCT patients had inferior results in 4 out of 6 tests. The physical performance of nontransplanted ALL patients did not differ from that of healthy controls. A higher physical exercise activity and a BMI below median positively correlated with better muscle performance, supporting the importance of encouraging ALL survivors to exercise and avoid obesity.
The effect of exercise and motor interventions on physical activity and motor outcomes during and after medical intervention for children and adolescents with acute lymphoblastic leukemia: A systematic review. [2021]Children with acute lymphoblastic leukemia (ALL) experience detrimental effects on motor function during and after chemotherapy. The objective of this systematic review was to evaluate the effect of exercise and motor interventions on physical activity and motor outcomes of children with ALL during and after chemotherapy.
Cross-Training and Resistance Training in Adults with Type B Acute Lymphoblastic Leukemia during the Induction Phase: A Randomized Blind Pilot Study. [2023]Patients with acute lymphoblastic leukemia (ALL) undergoing induction decrease their physical capacity, lose muscle mass, and decrease their quality of life (QOL). The safety, feasibility, and benefits of exercise during chemotherapy have been proven, but the effects of cross-training activities have yet to be analyzed. To measure the effects of cross-training on body composition, physical performance, and QOL, a blind randomized clinical trial was carried out. A total of 33 patients were included and randomized into a cross-training exercise group (CEG), a resistance exercise group (REG), and a control group (CG). During induction, patients received an exercise routine three to five days a week for 30 to 50 min each. Body composition, QOL, and physical performance were measured at baseline, up to discharge, and at a follow-up of two months. Body composition improved in the REG and CEG. In the CG, muscle mass decreased and fat mass increased (p = 0.020 and 0.020, respectively). The REG and CEG had significant positive improvements in physical performance compared to the CG. QOL showed no differences in any group (p = 0.340). Cross-training and resistance exercise are essential to improve body composition and physical performance during induction. Considering the prognostic value of physical performance, we propose integrated training exercises as adjuvant therapy in adult patients with ALL.
Feasibility and initial effectiveness of home exercise during maintenance therapy for childhood acute lymphoblastic leukemia. [2022]Children with acute lymphoblastic leukemia (ALL) are at increased risk of obesity and deconditioning from cancer therapy. This pilot study assessed feasibility/initial efficacy of an exercise intervention for patients with ALL undergoing maintenance therapy.
Physical activity during treatment in children with leukemia: a pilot study. [2017]The purpose of this pilot study was to measure physical activity (PA) levels in children undergoing treatment for acute lymphoblastic leukemia (ALL) and to compare the results with those from age-matched healthy children. We used the MTI Actigraph accelerometer to determine PA (during a 1 week period) in children (n = 7; age = 4-7 y) undergoing maintenance treatment for ALL and in age-matched controls (n = 7). The number of children accumulating at least 60 min of moderate-to-vigorous physical activity (MVPA) for 5 or more days of the week was 3 for the control group, whereas no children with ALL met this criterion. Significantly lower levels of total weekly time of MVPA were seen in children being treated for ALL (328 +/- 107 min) than in controls (506 +/- 175 min) (p
A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia. [2009]Reduced bone mineral density (BMD), altered body composition, impaired motor performance and passive ankle dorsiflexion are side effects of acute lymphoblastic leukemia (ALL) treatment. We performed a randomized study investigating whether an exercise program could prevent these side effects.
Physical activity and fitness in adolescent and young adult long-term survivors of childhood acute lymphoblastic leukaemia. [2021]There is a lack of data on physical activity (PA) and fitness of adolescent and young adult very long-term survivors of childhood acute lymphoblastic leukemia (ALL).