Intensity Modulated Radiation Therapy for Prostate Cancer
(SIB Trial)

Recruiting in Palo Alto (17 mi)

+1 other location

Overseen byWilliam A. Hall

Age: 18+

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Medical College of Wisconsin

No Placebo Group

Approved in 6 Jurisdictions

Trial Summary

What is the purpose of this trial?

The purpose of this study is to find out the effects (good and bad) of using newer technologies that allow very precise delivery of radiation. These newer technologies are Intensity Modulated Radiation Therapy (IMRT) and Image Guided Radiation Therapy (IGRT).

Research Team

William A. Hall

Principal Investigator

Medical College of Wisconsin

Eligibility Criteria

This trial is for men with prostate cancer that hasn't spread to other parts of the body. They must have a specific Gleason score, which measures cancer aggressiveness, and no history of chemotherapy or radiation in the pelvic area. Participants need to be able to perform daily activities without significant assistance (Karnofsky Performance Scale > 70).

Inclusion Criteria

My prostate cancer is at an early stage but has a high risk of spreading, or it's more advanced but hasn't spread to other parts.

I haven't had radiation or chemotherapy for my pelvic or prostate area, but I may have had hormone therapy.

I am able to care for myself and perform normal activities with minimal assistance.

See 4 more

Exclusion Criteria

I have had radiation therapy in the pelvic area before.

My cancer has spread to distant parts of my body.

I have had chemotherapy in the past.

See 2 more

Treatment Details

Interventions

Radiation Therapy (Radiation Therapy)

Trial OverviewThe study tests high-dose radiation therapy targeting lymph nodes using advanced technologies called Intensity Modulated Radiation Therapy (IMRT) and Image Guided Radiation Therapy (IGRT), aiming for precise delivery to improve treatment outcomes.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: IMRT & IGRT Radiation TherapyExperimental Treatment1 Intervention

In this study we will deliver a high dose of radiation to the pelvic lymph nodes of 56 Gy (Gy/Gray = measure of amount of radiation) and at the same time give a boost (additional) radiation to the prostate itself (to 70 Gy).

Radiation Therapy is already approved in Canada, Japan, China, Switzerland for the following indications: