3-Tesla MRI for Prostate Cancer

Recruiting in Palo Alto (17 mi)

Overseen byMichael Knopp, MD

Age: Any Age

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Cincinnati

No Placebo Group

Trial Summary

What is the purpose of this trial?

In standard clinical care, the prostate is imaged by magnetic resonance imaging (MRI) which is a procedure to take pictures of body structures by using a strong magnetic field and radio waves. The strength of the magnet used is expressed in the unit Tesla (T); a higher Tesla number means the magnet has stronger pull. Standard magnetic resonance imaging of the prostate uses a magnet 1.5 Tesla strong as well as a specialized endorectal coil (antenna) inserted into the body due to the limitations using an external body coil at this magnet strength. MRI using a 3 Tesla magnet has a theoretical advantage over imaging at 1.5 Tesla of creating a signal twice as strong that can be received by the antennas, resulting in better pictures. The goal of this study is to make the MRI procedure more comfortable for patients by using an external coil instead of an endorectal coil. With this study, researchers also want to help patients' health care teams, the surgeons in particular. Researchers will assess the impact of prostate MRI, without an endorectal coil, done at 3 Tesla and with an external body coil on helping doctors decide which approaches to disease therapy might be best for patients as well as correlate patients' study images with all other clinical imaging

Eligibility Criteria

This trial is for patients with known or suspected prostate cancer, specifically those with a Gleason's score >= 7 and PSA > 10ng/dl. Participants must have proper kidney function (eGFR >= 30 mL/min/1.73m^2). They should be able to follow the study procedures and communicate effectively. Those with severe renal issues, bioimplants like pacemakers, metal in their body, or extreme anxiety are excluded.

Inclusion Criteria

I have prostate cancer with a Gleason score of 7 or higher and a PSA over 10ng/dl.

I will sign a consent form before getting an MRI as per Ohio State University's rules.

My kidney function test shows a filtration rate of at least 30 mL/min.

Exclusion Criteria

I have metal clips or staples from surgery in my body.

I experience significant anxiety or claustrophobia.

I have heart problems or issues with blood circulation and sweating.

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Treatment Details

Interventions

3-Tesla magnetic resonance imaging (3T MRI) (Procedure)
diffusion-weighted magnetic resonance imaging (Procedure)
dynamic contrast-enhanced magnetic resonance imaging (Procedure)
magnetic resonance spectroscopic imaging (Procedure)

Trial OverviewThe trial tests if using a stronger magnet (3 Tesla MRI) without an uncomfortable internal coil can still provide clear images of the prostate for better treatment planning. It compares this method against standard imaging practices to see if it offers more comfort without compromising image quality.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: Diagnostic (3T MRI)Experimental Treatment4 Interventions

Patients undergo 3T MRI, including DCE-MRI, diffusion-weighted MRI, amide-proton-transfer MRI, and MR spectroscopy scans. Patients may undergo an additional 3T MRI scan at least 24 hours after the initial scan.