Narrow Band Phototherapy for Psoriasis

(LITE Trial)

Recruiting in Palo Alto (17 mi)

+41 other locations

Overseen by Joel M. Gelfand, MD,MSCE

Age: Any Age

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Pennsylvania

No Placebo Group

Trial Summary

What is the purpose of this trial?

To compare the effectiveness, safety (tolerability), and duration of treatment response at 12 weeks of home versus office-based narrowband ultraviolet B phototherapy for the treatment of psoriasis

Research Team

Joel M. Gelfand, MD,MSCE

Principal Investigator

University of Pennsylvania

Eligibility Criteria

Inclusion Criteria

You have psoriasis mainly on your torso and limbs, and your doctor thinks you may benefit from phototherapy.

Age 12 or older

New or established patient in the practice

Exclusion Criteria

You have tried light therapy before but it didn't work for you, or you received light therapy in the 14 days leading up to the study.

Patients who are judged unable or unwilling to comply with either in office or in home phototherapy due to time, work, school, or other financial constraints

Patients judged unable to follow home phototherapy protocol due to failure to demonstrate understanding of the following: How to operate the phototherapy device, How to follow the dosing protocol, Requirement to wear protective eyewear and genital protection equipment

Treatment Details

Interventions

• Daavlin 7 series 3 panel narrow band phototherapy home units (Phototherapy)
• narrow band phototherapy clinic units (Phototherapy)

Participant Groups

Group I: Office Based Phototherapy Experimental Treatment 1 Intervention

Patients randomized to this arm will receive narrow band phototherapy in a clinical setting via narrow band phototherapy clinic units.

Group II: Home Based Phototherapy Active Control 1 Intervention

Patients randomized to this arm will receive narrow band phototherapy in a home setting via Daavlin 7 series 3 panel narrow band phototherapy home units.

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials

2,118

Recruited

45,270,000+

Dr. Joan Lau

University of Pennsylvania

Chief Executive Officer since 2020

PhD in Neuroscience from the University of Cincinnati College of Medicine, MBA from the Wharton School of Business, BS in Bioengineering from the University of Pennsylvania

Dr. Robert Iannone

University of Pennsylvania

Chief Medical Officer since 2019

MD from Yale University, MSCE from the University of Pennsylvania

University of Utah

Collaborator

Trials

1,169

Recruited

1,623,000+

Jeffrey Wilkins

University of Utah

Chief Medical Officer since 2022

MD from Meharry Medical College

Stephen Tullman

University of Utah

Chief Executive Officer since 2022

BS in Accounting from Rutgers University

National Psoriasis Foundation

Collaborator

Trials

12

Recruited

1,900+

Patient-Centered Outcomes Research Institute

Collaborator

Trials

592

Recruited

27,110,000+

Nakela L. Cook

Patient-Centered Outcomes Research Institute

Chief Executive Officer since 2020

MD, MPH

Harv Feldman

Patient-Centered Outcomes Research Institute

Chief Medical Officer

MD, MSCE