Theta-Burst Stimulation for Language Disorders
(TAFE Trial)
Trial Summary
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Research shows that intermittent theta burst stimulation (iTBS) can improve language function in people with post-stroke aphasia by enhancing activity in brain areas responsible for language. Additionally, continuous theta burst stimulation (cTBS) has been found to improve language performance by targeting specific brain regions involved in language processing.
12345Theta-burst stimulation, including both continuous (cTBS) and intermittent (iTBS) forms, has been studied for safety in conditions like major depressive disorder. Studies have shown it is generally safe and well-tolerated, though some participants may experience mild side effects.
16789Theta-burst stimulation (TBS) is unique because it uses magnetic pulses to influence brain activity, potentially improving language function in people with language disorders. Unlike traditional therapies, TBS can be applied in short sessions and targets specific brain areas involved in language processing, offering a novel approach for conditions like post-stroke aphasia.
1251011Eligibility Criteria
This trial is for individuals with reading and language disorders, as well as healthy control subjects. Participants must be willing to undergo cognitive testing, MRI scans, TMS stimulation, and perform various tasks related to language, reading, and motor skills.Inclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive transcranial magnetic stimulation (TMS) and undergo reading, language, and cognitive testing
Follow-up
Participants are monitored for changes in reading and language behavior after TMS
Participant Groups
cTBS is already approved in United States for the following indications:
- Major Depressive Disorder (using iTBS protocol)