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Inspiratory Muscle Strength Training for High Blood Pressure

N/A

Recruiting

Led By Daniel H Craighead, PhD

Research Sponsored by University of Colorado, Boulder

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 50 years and older

Be older than 18 years old

Must not have

Younger than age 50

History of uncontrolled hypertension (systolic blood pressure >180 mmHg and/or diastolic blood pressure >120 mmHg)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months

Awards & highlights

No Placebo-Only Group

Summary

This trial will test whether a time-efficient intervention, high-resistance inspiratory muscle strength training, can lower blood pressure and improve endothelial, cerebrovascular, and cognitive function in adults with above-normal blood pressure.

Who is the study for?

Adults aged 50 or older with high blood pressure (systolic BP of at least 120 mmHg), a BMI under 40, and stable weight are eligible for this trial. They must be non-smokers, not on changing medication regimens, able to consent, and have no history of uncontrolled hypertension or regular vigorous exercise.

What is being tested?

The trial is testing whether a time-efficient breathing exercise called Inspiratory Muscle Strength Training (IMST) can lower systolic blood pressure more effectively than brisk walking. Participants will do one of these activities for three months to see if there's an improvement in blood pressure and vascular health.

What are the potential side effects?

Potential side effects from the interventions may include muscle soreness from IMST or typical exercise-related discomfort such as joint pain or fatigue from brisk walking.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 50 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am under 50 years old.

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My blood pressure is not higher than 180/120 mmHg.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change from baseline in resting systolic and diastolic blood pressure

Secondary study objectives

Change from baseline endothelial function at 3 months

Other study objectives

Change from baseline ambulatory systolic and diastolic blood pressure at 3 months

Change from baseline in aortic stiffness at 3 months

Change from baseline in cerebrovascular reactivity at 3 months

+12 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Inspiratory muscle strength trainingExperimental Treatment1 Intervention

Using a handheld device, participants will perform 30 breaths a day at 75% of maximal inspiratory pressure, six days a week, for three months.

Group II: Brisk walkingActive Control1 Intervention

Participants will walk for 25 minutes a day, six days a week, for three months at a target heart rate of 40-60% heart rate reserve. Heart rate will be monitored with a heart rate monitor.

0 / 3Eligibility criteria met