Positive Airway Pressure for Sleep Apnea (PAP-SAP Trial)

Palo Alto (17 mi)

Overseen byGhada Bourjeily, MD

Age: 18+

Sex: Female

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: The Miriam Hospital

Trial Summary

What is the purpose of this trial?This study is testing the hypothesis of whether continuous positive airway pressure (CPAP) therapy improves placental histopathology and secretory function. The main aims of the study are to identify shared mechanisms between obstructive sleep apnea and preeclampsia, both common highly morbid conditions.

Eligibility Criteria

This trial is for pregnant women who snore, are obese (BMI >30), over 18 years old, less than 13 weeks into their pregnancy, planning to deliver at Women and Infants Hospital of Rhode Island, and can consent. It's not for those with severe illnesses or conditions that affect participation, risk of preterm delivery due to incompetent cervix, intolerance to PAP therapy, drowsy driving issues, extreme low oxygen levels during sleep study, fetuses with congenital anomalies, severe high blood pressure at enrollment or serious heart/lung diseases.

Treatment Details

The PAP-SAP study is examining if using continuous positive airway pressure (CPAP) therapy can improve the health and function of the placenta in pregnant women who snore but don't have obstructive sleep apnea. The research aims to find connections between sleep apnea and preeclampsia by looking at changes in the placenta.

2Treatment groups

Active Control

Placebo Group

Group I: Positive Airway PressureActive Control2 Interventions

Positive airway pressure and nasal dilator strips during sleep.

Group II: Nasal Dilator StripsPlacebo Group1 Intervention

Nasal dilator strips during sleep.