Physical Activity Program for Reducing Blood Pressure in Sleep Apnea Patients with Resistant Hypertension

(RAP Trial)

Recruiting in Palo Alto (17 mi)

+2 other locations

Overseen by Jean-Louis Pépin, Pr MD PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: AGIR à Dom

No Placebo Group

Approved in 1 Jurisdiction

Trial Summary

What is the purpose of this trial?

Investigators hypothesize that CPAP treatment for suppressing OSAS in combination with a physical activity program will optimize 24-hour blood pressure control in patients with OSA-related resistant hypertension.

Research Team

Jean-Louis Pépin, Pr MD PhD

Principal Investigator

Laboratoire EFCR, CHU de Grenoble, 38043, Grenoble, France

Eligibility Criteria

Inclusion Criteria

Patient with an obstructive sleep apnea (apnea-hypopnea index > or equal to 15)

Patient with resistant hypertension uncontrolled by 3 or more antihypertensive agents

Ambulatory patient

Treatment Details

Interventions

• Physical activity (Behavioural Intervention)

Participant Groups

Group I: Physical activity Experimental Treatment 1 Intervention

Obstructive sleep apnea and resistant hypertension controlled + physical activity

Group II: Control Group Active Control 1 Intervention

Obstructive sleep apnea and resistant hypertension controlled

Who Is Running the Clinical Trial?

AGIR à Dom

Lead Sponsor

Trials

35

Recruited

5,100+

University Hospital, Grenoble

Collaborator

Trials

840

Recruited

387,000+

Yassine Lakhnech

University Hospital, Grenoble

Chief Executive Officer since 2020

Graduate of the University of Kiel, specialized in program verification and provable security

Prof. Pierre-Yves Benhamou

University Hospital, Grenoble

Chief Medical Officer since 2018

MD, Professor of Endocrinology and Metabolism