Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure

(IMPROVENT Trial)

Recruiting in Palo Alto (17 mi)

Overseen by Colin Grissom, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Intermountain Health Care, Inc.

No Placebo Group

Trial Summary

What is the purpose of this trial?

This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a proven standardized lung protective ventilation protocol in the new electronic medical record system iCentra across all Intermountain Healthcare hospitals. Approximately 14,000 records will be accessed for this study from a database of mechanically ventilated patients established for quality improvement purposes. The investigators hypothesize that implementation of a standardized computerized lung protective ventilation protocol across all Intermountain Healthcare hospitals will be feasible, will decrease initial tidal volumes to the target 6 ml/kg PBW, and will improve outcomes. The objectives of this study are to: * Determine if the implementation of lung protective ventilation (with a 6 ml/kg PBW tidal volume ventilation protocol on initiation of mechanical ventilation) improves outcomes in patients with acute respiratory failure requiring mechanical ventilation * Determine if the implementation of lung protective ventilation (with a 6 ml/kg PBW tidal volume ventilation protocol on initiation of mechanical ventilation) improves outcomes in the sub-group of patients with the acute respiratory distress syndrome (ARDS) * Measure compliance with the implementation of a computerized lung protective ventilation protocol at 12 Intermountain Healthcare hospitals

Research Team

Colin Grissom, MD

Principal Investigator

Intermountain Health Care, Inc.

Eligibility Criteria

Inclusion Criteria

Initiation of mechanical ventilation in the emergency department or intensive care unit at an Intermountain Healthcare hospital

Age ≥ 18 years

Treatment Details

Interventions

• Implementation of Lung Protective Ventilation (Lung Protective Ventilation Protocol)

Who Is Running the Clinical Trial?

Intermountain Health Care, Inc.

Lead Sponsor

Trials

142

Recruited

1,965,000+

Brent James

Intermountain Health Care, Inc.

Chief Medical Officer since 2010

MD from University of Utah

Rob Allen

Intermountain Health Care, Inc.

Chief Executive Officer since 2022

Bachelor's degree in Business Administration