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MRI Imaging for Thymoma

N/A
Waitlist Available
Led By Marcelo F Benveniste
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
All adult patients scheduled to meet with a thoracic surgeon from MD Anderson Cancer Center (ACC) for resection of newly diagnosed thymoma or thymoma recurrence in the chest and scheduled for surgery
Be older than 18 years old
Must not have
Children, defined as individuals younger than 18 years old on the preoperative visit with the thoracic surgeon
Patients with glomerular filtration rate (GFR) < 60 ml/min, who will have their MRI performed without contrast
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 10 years
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing whether MRI is more accurate than CT in imaging the inside of the chest in patients with thymoma.

Who is the study for?
This trial is for adults with newly diagnosed or recurrent thymoma who are scheduled for surgery at MD Anderson Cancer Center. It's not open to those under 18, pregnant women, patients with metal in their chest or pacemakers, known allergies to MRI contrast agents (gadolinium), or severe kidney issues.
What is being tested?
The study is testing the effectiveness of an MRI scan versus a standard CT scan in accurately imaging and assessing the spread of thymoma within the chest before surgical removal.
What are the potential side effects?
There may be minimal side effects from the MRI procedure itself; however, individuals allergic to gadolinium might experience reactions if contrast is used. Kidney function could also be affected by contrasts used during imaging.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am scheduled for surgery at MD Anderson for a new or recurring thymoma.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am under 18 years old and have seen a thoracic surgeon.
Select...
My kidney function is reduced, so my MRI will be without contrast.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 10 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 10 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Accuracy of magnetic resonance imaging (MRI) staging
Secondary study objectives
Accuracy of fast novel MRI sequences
Accuracy of phrenic nerve paralysis by functional MRI

Side effects data

From 2022 Phase 3 trial • 53 Patients • NCT00033293
19%
87900-Vomiting(targeted toxicity)
15%
11400-Agitation
8%
58700-Nystagmus
8%
16800-Bladder infection
8%
11600-Alanine aminotransferase increased
8%
44800-Infections and infestations - Other specify
4%
69700-Rash maculo-papular(targeted toxicity)
4%
41400-Hyperglycemia(targeted toxicity)
4%
58300-Neutrophil count decreased
4%
33900-Fever
4%
33300-Febrile neutropenia
4%
20500-Catheter related infection
4%
42600-Hypoalbuminemia
4%
43100-Hypokalemia
4%
88500-White blood cell decreased
4%
41300-Hypercalcemia
4%
42700-Hypocalcemia
4%
15300-Ataxia
4%
64400-Personality change
4%
13200-Anemia
4%
57600-Nausea(targeted toxicity)
4%
13500-Anorexia
4%
15000-Aspartate aminotransferase increased
4%
25700-Diarrhea
4%
41600-Hyperkalemia
4%
41500-Hyperhidrosis
100%
80%
60%
40%
20%
0%
Study treatment Arm
Arm I (Chemotherapy, Immunoglobulin Therapy)
Arm II (Chemotherapy, Observation)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Diagnostic (MRI, diaphragm fluoroscopy)Experimental Treatment2 Interventions
Patients undergo an MRI scan over 45-60 minutes and a diaphragm fluoroscopy 30 days before surgery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Magnetic Resonance Imaging
2017
Completed Phase 3
~1180

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,958 Previous Clinical Trials
41,112,540 Total Patients Enrolled
22 Trials studying Thymoma
2,724 Patients Enrolled for Thymoma
M.D. Anderson Cancer CenterLead Sponsor
3,074 Previous Clinical Trials
1,803,505 Total Patients Enrolled
3 Trials studying Thymoma
76 Patients Enrolled for Thymoma
Marcelo F BenvenistePrincipal InvestigatorM.D. Anderson Cancer Center
~1 spots leftby Apr 2025
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