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Electrical Stimulation for Tremor

N/A

Waitlist Available

Led By Jose L Pons, PhD

Research Sponsored by Shirley Ryan AbilityLab

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

ET Patients: Diagnosis of ET (Tremor Research investigation Group criteria) by a physician

ET Patients: Normal hearing and (corrected) vision

Must not have

Healthy Participants: Prior neurosurgical procedures

Healthy Participants: History of significant head trauma (i.e., extended loss of consciousness, neurological damage)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up assessment will be performed before, immediately after, and 30 minutes after the administration of the intervention in a single visit

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to study how electrical stimulation impacts proprioception and fine motor control in the arm. They will use different types of electrical stimulation and various assessments to measure the effects on healthy individuals and patients with

Who is the study for?

This trial is for adults aged 18-80 with essential tremor (ET) and healthy individuals without tremors. ET patients must have a moderate-severe wrist tremor, no skull lesions or history of significant head trauma, stable medication doses, and normal hearing/vision. Healthy participants need normal neurological function and cannot be pregnant or have a history of substance abuse.

What is being tested?

The study tests the effects of sensory electrical stimulation on proprioception (sense of body position) and motor control in people with ET and healthy controls. It involves non-invasive electrical stimulation strategies, muscle activity recording (HD-EMG), arm movement tracking, and clinical assessments.

What are the potential side effects?

Potential side effects may include discomfort at the stimulation site, skin irritation from electrodes, temporary changes in sensation or muscle twitching during electrical stimulation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with Essential Tremor by a doctor.

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My hearing and vision, with correction if needed, are normal.

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I do not have any neurological disorders.

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I can understand and speak English.

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I am between 18 and 80 years old.

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I do not have tremors.

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I have a moderate to severe hand tremor that worsens when I hold my arm out.

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I have normal hearing and vision (with glasses/contact lenses if needed).

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I am between 18 and 80 years old.

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I have never had a brain or skull lesion.

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I have never had skull surgery or lesions.

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My medication doses have been stable for at least 30 days before joining the study.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had brain surgery before.

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I have had a serious head injury.

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I do not have Parkinson's disease or similar symptoms.

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I have had brain surgery before.

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I have had a serious head injury with long unconsciousness or brain damage.

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I do not have conditions like epilepsy or severe arthritis affecting my movement.

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I have Parkinson's disease symptoms.

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I don't have any health conditions that would affect my participation in the study.

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I do not have any health or mental conditions that would affect my participation.

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I have a known structural brain lesion.

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I do not have conditions like epilepsy or stroke that affect my limb movements.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ assessment will be performed before, immediately after, and 30 minutes after the administration of the intervention in a single visit

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~assessment will be performed before, immediately after, and 30 minutes after the administration of the intervention in a single visit

This trial's timeline: 3 weeks for screening, Varies for treatment, and assessment will be performed before, immediately after, and 30 minutes after the administration of the intervention in a single visit for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Fine motor control as assessed by visuomotor tracking performance

Force perception via force matching tasks

Position perception via position matching tasks

+1 more

Secondary study objectives

Tremor assessment using TETRAS

Tremor assessment using arm kinematics

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Transcutaneous asESExperimental Treatment2 Interventions

Participants will be administered transcutaneous afferent-specific electrical stimulation in the upper limb using conductive pads targeting the median and radial nerves at the wrist

Group II: Percutaneous asESExperimental Treatment2 Interventions

Participants will be administered percutaneous afferent-specific electrical stimulation in the upper limb using intramuscular leads targeting the flexor and extensor muscles of the wrist

0 / 23Eligibility criteria met