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OCT Angiography for Retinopathy (OCTA-RVD Trial)

N/A

Recruiting

Led By Amir Kashani, MD, MPH

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 years

Awards & highlights

No Placebo-Only Group

Summary

This trial will help better define when someone with retinal vascular disease is progressing or regressing so that treatment can be more accurately given.

Who is the study for?

This trial is for individuals with retinal vascular diseases like diabetic retinopathy or retinal vein occlusion, as well as those with high blood pressure that may affect the retina. Participants should be able to undergo regular imaging tests to track changes in their eye condition over time.

What is being tested?

The study is testing different eye imaging techniques: Swept-Source OCT Angiography, Spectral-Domain OCT Angiography, Fundus Imaging, and Axial Length Measurement Device. It aims to observe how these methods can detect changes in the retina due to disease progression or treatment effects.

What are the potential side effects?

Since this trial involves non-invasive imaging of the eyes, side effects are minimal but may include temporary discomfort from bright lights during imaging or mild eye strain.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Correlation of Imaging

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups

Experimental Treatment

Group I: Hypertension OnlyExperimental Treatment4 Interventions

Subjects in this group only have hypertension with or without ocular pathology related to hypertension. Some subjects in this arm may undergo retinal vascular reactivity assessments.

Group II: Diabetics with and without Diabetic Retinopathy OnlyExperimental Treatment4 Interventions

Subjects in this group only have diabetes with or without diabetic retinopathy. Some subjects in this arm will undergo retinal vascular reactivity assessments.

Group III: Diabetics w/ or w/o Diabetic Retinopathy & HypertensionExperimental Treatment4 Interventions

Subjects in this group have diabetes with or without diabetic retinopathy and hypertension with or without ocular pathology related to hypertension. Some subjects in this arm may undergo retinal vascular reactivity assessments.

Group IV: ControlsExperimental Treatment4 Interventions

Subjects in this group do not have any ocular pathology and are also not hypertensive. Some subjects in this arm will undergo retinal vascular reactivity assessments.

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