Popular Trials
Monoclonal Antibodies
Combination Therapy for Ulcerative Colitis
This trial is testing a new medication, JNJ-78934804, for patients with severe ulcerative colitis who haven't had success with other treatments. The medication aims to reduce inflammation by targeting the immune system.
Monoclonal Antibodies
JNJ-77242113 for Ulcerative Colitis
This trial is testing a new medication called JNJ-77242113 to see if it can help people with moderately to severely active ulcerative colitis. The medication aims to reduce inflammation in the colon by calming the immune system. Researchers want to find out if it is safe and effective.
Monoclonal Antibodies
TEV-48574 for Inflammatory Bowel Disease
This trial tests a new drug called TEV-48574, given as a shot periodically, in adults with inflammatory bowel disease. It aims to see how well the drug works, how safe it is, and how the body reacts to it.
MORF-057 for Ulcerative Colitis
This trial is testing a new medication called MORF-057 in adults with serious Ulcerative Colitis. The goal is to see if it can reduce inflammation in the gut and help the colon heal. Patients who don't respond well to current treatments might benefit from this new option.
Monoclonal Antibodies
Guselkumab for Ulcerative Colitis
This trial tests an injectable medication called guselkumab on people with severe ulcerative colitis. It aims to see if blocking a protein that causes inflammation can help these patients achieve remission.
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Trials for Colitis Patients
Behavioural Intervention
Fasting Mimicking Diet for Ulcerative Colitis
This trial is testing a special diet that mimics fasting in people with mild to moderate Ulcerative Colitis. The diet allows people to eat certain safe foods while getting the benefits of fasting. Researchers want to see if this diet can reduce inflammation and improve quality of life for these patients.
Oral NX-13 for Ulcerative Colitis
This trial is testing a new treatment for people with moderate to severe ulcerative colitis. The goal is to see if this treatment can reduce inflammation and improve symptoms. The study includes a period to monitor the effects over time.
Cruciferous Vegetables
Broccoli Sprouts for Ulcerative Colitis
This trial is testing if eating broccoli sprouts can help patients with mild ulcerative colitis by increasing a compound called sulforaphane in their bodies, which may reduce inflammation. Sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables such as broccoli and brussels sprouts, has a variety of biological functions.
Trials for ASC Patients
Behavioural Intervention
Fasting Mimicking Diet for Ulcerative Colitis
This trial is testing a special diet that mimics fasting in people with mild to moderate Ulcerative Colitis. The diet allows people to eat certain safe foods while getting the benefits of fasting. Researchers want to see if this diet can reduce inflammation and improve quality of life for these patients.
Oral NX-13 for Ulcerative Colitis
This trial is testing a new treatment for people with moderate to severe ulcerative colitis. The goal is to see if this treatment can reduce inflammation and improve symptoms. The study includes a period to monitor the effects over time.
Cruciferous Vegetables
Broccoli Sprouts for Ulcerative Colitis
This trial is testing if eating broccoli sprouts can help patients with mild ulcerative colitis by increasing a compound called sulforaphane in their bodies, which may reduce inflammation. Sulforaphane (SFN), an isothiocyanate present in cruciferous vegetables such as broccoli and brussels sprouts, has a variety of biological functions.
Phase 3 Trials
Monoclonal Antibodies
Guselkumab for Pediatric Ulcerative Colitis
This trial is testing guselkumab, a medication that reduces inflammation, in children with severe ulcerative colitis who have already shown improvement with earlier treatment. It works by blocking a protein to reduce immune system-related swelling and irritation. Guselkumab has shown benefit in treating inflammatory conditions, with reports of substantial improvement in patients.
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Frequently Asked Questions
Introduction to ulcerative colitis
What are the top hospitals conducting ulcerative colitis research?
For individuals living with ulcerative colitis, finding effective treatments and potential breakthroughs is of paramount importance. In the city of Tyler, Texas, the Tyler Research Institute leads the way in clinical trials for this condition. With a remarkable nine ongoing trials and a total of 21 completed studies dedicated to ulcerative colitis, this institute has been at the forefront since their first recorded trial in 2012.
Meanwhile, in Chesterfield, Michigan, the Clinical Research Institute of Michigan is making significant strides as well. They currently have eight active clinical trials focused on ulcerative colitis and have conducted an impressive 25 studies to date since initiating their inaugural trial back in 2004.
Heading south to Naples, Florida, we find another prominent player in gastroenterological research: The Gastroenterology Group of Naples. With six active trials and a history that includes 22 previously conducted studies since launching their first ulcerative colitis trial in 2008 they continue to contribute significantly towards advancements in treatment options.
Notably contributing from Nashville is Vanderbilt University Medical Center where they are conducting six active clinical tests related specifically to ulcerative colitis; adding up over three decades worth through thirty-one previous examinations carried out ever since starting its trial runs precisely seventeen years ago (in2004).
Lastly joining this list is Chevy Chase Clinical Research located at Chevy Chase MD which presently accommodates half-a-dozen ulcers-colon affiliated exploratory endeavors furthermore establishing twenty-three such .surgeries marked within fifteen years since beginning its evaluation forms just five years after (in2006).
These hospitals serve as beacons of hope for those affected by ulcerative colitis worldwide. Their dedication to research brings us closer each day not only toward better understanding but also more effective treatments for this chronic inflammatory bowel disease.
Which are the best cities for ulcerative colitis clinical trials?
When it comes to ulcerative colitis clinical trials, several cities emerge as leading hubs for research and development. New york City boasts 50 active trials, focusing on promising treatments like tofacitinib, Ozanimod, and risankizumab. Miami, Florida follows closely with 44 ongoing studies exploring interventions such as ABX464 50mg and Upadacitinib (ABT-494). Houston, Texas also stands out with 40 active trials investigating treatments like Ozanimod and Mirikizumab. These cities offer individuals with ulcerative colitis access to cutting-edge clinical trials that fuel advancements in care and bring hope for improved outcomes.
Which are the top treatments for ulcerative colitis being explored in clinical trials?
Exciting progress is being made in the realm of ulcerative colitis treatments, with several promising contenders emerging from clinical trials. Leading the pack is etrasimod, currently undergoing testing in three active trials and amassing a total of 10 all-time studies dedicated to addressing this condition since its debut in 2015. Mirikizumab follows closely behind, also participating in three ongoing trials and accumulating six all-time ulcerative colitis studies since its introduction in 2015. Additionally, ozanimod shows promise with two active trials and eight all-time evaluations for ulcerative colitis since its listing began in 2012. Finally, vedolizumab remains an important contender with two ongoing trials and an impressive history of 24 overall investigations focusing on ulcerative colitis treatment since it was first listed back in 2007. These innovative therapies bring hope for improved outcomes for individuals battling this challenging disease.
What are the most recent clinical trials for ulcerative colitis?
Exciting developments are underway in the field of ulcerative colitis treatment, with recent clinical trials offering new possibilities for patients. One such trial is focusing on an open-label induction phase to evaluate the efficacy and safety of a potential treatment for ulcerative colitis. Another study explores the combination of oral Upadacitinib with methylprednisolone plus cyclosporine infusion as a therapeutic approach for this condition. Additionally, high-dose budesonide is being investigated in another trial to assess its effectiveness in managing symptoms related to ulcerative colitis. The introduction of PRIM-DJ2727 - FROZEN and mirikizumab also bring hope as potential therapies undergoing Phase 1 and Phase 3 evaluations respectively, aiming to improve outcomes for individuals living with ulcerative colitis.
What ulcerative colitis clinical trials were recently completed?
Several recent clinical trials have made significant strides in the field of ulcerative colitis research. Notably, Bacainn Therapeutics, Inc. completed a trial investigating the effectiveness of BT051 200 mg in November 2021. Earlier in June 2021, Bridge Biotherapeutics, Inc.'s study on BBT-401-1S concluded with promising results. In May 2021, Landos Biopharma Inc.'s NX-13 250mg IR trial also reached completion and showed encouraging outcomes. These achievements highlight the dedication of various pharmaceutical companies to developing innovative therapies for patients suffering from ulcerative colitis.